Каталог - Технологии, Анализи, Експертизи (2014)


Научен симпозиум "Beneficial And Pathogenic Microbes For Healthier And Safety Foods" 8-9 Април, 2015


БАН в медиите

Обръщение към българския народ от Българската православна църква – Българска Патриаршия и Българска академия на науките


Награда за Института в Конкурса за високи научни постижения по случай 145-годишнината на Академията


Изложба на Институт по микробиология по случай 145- годишнината на БАН


Правилник за вътрешния ред на Институт по микробиология "Стефан Ангелов", БАН


Годишни отчети на Институт по микробиология "Стефан Ангелов"


Институт по микробиология отдава помещения под наем


Правилник за   придобиване на академични степени и заемане на академични длъжности в Институт по микробиология, БАН


Институтът по микробиология "Стефан Ангелов" при БАН удостоен с Отличието "ЗЛАТЕН ПЕЧАТ" за ЕВРОПЕЙСКИ МЕНИДЖМЪНТ от Съвета на Европейската научна и културна общност


Закон за развитие на академичния състав в Република България


Правилник за прилагане на Закона за развитието на академичния състав в Република България




science daily 




































































Българска Академия на Науките


Министерство на Образованието  и Науката


Фонд Научни изследвания


Централна библиотека на БАН


Съюз на учените в България


European Comission:
Horizon 2020


Institut Pasteur






PubMed Cenral


















Laboratory of Infectious Immunology and Inflammation


Head: Professor Nina Ivanovska, DSc


tel: +359 2 979 31 95





Assist. Professor Valeriya Gyurkovska, PhD, 

Assist. Professor Tzvetanka Stefanova

PhD student Petya Ganova,

Petya Stoyanova, VD, Head of the Animal House




Main research topics


Candida albicans infections, Rheumatoid arthritis, Osteoarthritis, Complement system



Main achievements


The results of the Laboratory of Infectious Immunology and Inflammation contribute to the experimental immunology and immunotherapy. The elaborated experimental mouse models of rheumatoid arthritis and osteoarthritis allow the investigation of the pathogenesis of joint disorders and are suitable for evaluation of potential anti-arthritic agents. The main topics of the laboratory are: 1) to dissect key biological and molecular pathways in acute and chronic inflammatory disorders and diseases, and to understand their relevance to the disease pathology, and 2) to develop new tools and approaches for the prediction, prevention and management of the abnormal immune responses. For the first time, the relationship between the mechanisms of innate immunity (complement system) and the processes of joint destruction has been established and an in vitro model for generation of erosive cells has been developed. With clinical meaning are the results obtained in arthritic patients, which help the identification of biochemical markers characteristic for active and inactive arthritic process. For the first time, the mechanism of action of tyrosine kinase inhibitor tyrphostin AG490 in a model of osteoarthritis has been studied precisely.

Current Projects


Mechanisms of action of TNF-related apoptosis-inducing ligand (TRAIL) in the development of sepsis and multiple organ dysfunction syndrome (MODS). 2017-2019, Project leader: Assistant Professor Valeriya Simeonova Gyurkovska, PhD, NSF

Selected Publications


  • Gyurkovska V., Philipov S., Kostova N., Ivanovska N. Acetylated derivative of glaucine inhibits joint inflammation in collagenase-induced osteoarthritis. Immunopharmacol. Immunotoxicol., 2015 Feb;37(1):56-62. doi: 10.3109/08923973.2014.972414. Epub 2014 Oct 20.

  • Gyurkovska V., Stefanova T., Dimitrova P., Danova S., Tropcheva R., Ivanovska N. Tyrosine kinase inhibitor tyrphostin AG490 retards chronic joint inflammation in mice. Inflammation, 37, 2014, 995-1005, ISSN 0360-3997.

  • Dupont A., Mohamed F., Glenn S., Francescut L., Adib R., Byrne S., Brewin S., Elliott I., Richards L., Dimitrova P., Schwaeble W., Ivanovska N., Kadioglu D., Machado L.R, Andrew P.W., Stover C. Septicaemia models using Streptococcus pneumoniae and Listeria monocytogenes: understanding the role of complement properdin. Med. Microbiol. Immunol., 2014, 1-15, ISSN 0300-8584.

  • Gyurkovska V., Stefanova T., Dimitrova P., Danova S., Tropcheva R., Ivanovska N. Tyrosine kinase inhibitor tyrphostin AG490 retards chronic joint inflammation in mice. Inflammation, 37, 2014, 995-1005, ISSN 0360-3997.

  • Gyurkovska V, Dimitrova P and Ivanovska N. Tyrosine kinase inhibitor Tyrphostin AG490 inhibits osteoclast differentiation in collagenase-induced osteoarthritis. Eur. J. Inflam., 2014, 12(2): 329-340  ISSN: 1721-727X

  • Georgiev M.I., Ivanovska N., Alipieva K., Dimitrova P., Verpoorte R. Harpagoside: From Kalahari Desert to pharmacy shelf. Phytochemistry, 92, 2013, 8-15, ISSN 0031-9422.

  • Dimitrova P., Ivanovska N. Tyrphostins as a promising therapeutic tool in inflammation-related conditions. OA Inflammation 1, 2013, 4. ISSN 2052-787X.

  • Dimitrova P., Ivanovska N., Belenska L., Milanova V., Schwaeble W., Stover C. Abrogated RANKL expression in properdin-deficient mice is associated with better outcome from collagen-antibody-induced arthritis. Arthritis Res. Ther., 2012, 14: R173.

  • Dimitrova P., Danova S., Ivanovska N. Pro-inflammatory action of Candida albicans DNA in zymosan-induced arthritis. Inflammation Res., 2012, 61: 649-656. ISSN: 1420-908X

  • Dimitrova P., Kostadinova E., Milanova V., Alipieva K., Georgiev M., and Ivanovska N. Antiinflammatory properties of extracts and compounds isolated from verbascum xanthophoeniceum griseb. Phytotherapy Res., 2012, 26: 1681-1687.  ISSN:1099-1573

  • Dimitrova P., Toncheva A., Gyurkovska V., Ivanovska N. Involvement of soluble receptor activator of nuclear factor-κB ligand (sRANKL) in collagenase-induced murine osteoarthritis and human osteoarthritis. Rheumat. Intеrnat., 2012, 32 (5), 1317-1325. ISSN:0172-8172

  • Dimitrova P., Georgiev M.I., Khan M.T.H., Ivanovska N. Evaluation of Verbascum species and harpagoside in models of acute and chronic inflammation. Central Eur. J. Biol., 2012, 8: 186-194. ISSN: 1895-104X 

  • Stefanova, T., Nikolova, N., Neychev, H., Zlabinger, G. Phagocytosis and killing of Salmonella by 7-hydroxycoumarin activated macrophages. Immunol. Invest., 41, 2012, 199-213. ISSN, 0882-0139. ISSN: 0882-0139

  • Gyurkovska, V., Alipieva, K., Maciuk A., Dimitrova, P., Haas, C., Bley, T., Georgiev, M. Anti-inflammatory activity of Devil's claw in vitro systems and their active constituents. Food Chemistry, 125, 2011, 171-178. ISSN: 0308-8146

  • Ivanovska, N., and P., Dimitrova. Bone resorption and remodeling in murine collagenase-induced osteoarthritis after administration of glucosamine. Arthritis Res. Ther., 2011:13, R44.

  • Dimitrova, P., and Ivanovska N. How important are innate immunity cells in osteoarthritis pathology. In: Osteoarthritis. InTech, Rijeka, Croatia, 2011. ISBN:979-953-307-082-6.

  • Dimitrova, P., Toncheva, A., Gyurkovska V, Ivanovska N. Involvement of soluble receptor activator of nuclear factor-κB ligand (sRANKL) in collagenase-induced murine osteoarthritis and human osteoarthritis. Rheumatol. Internat., 3, 2011. ISSN:0172-8172.

  • Dimitrova, P., Ivanovska, N., Schwaeble, W., Gyurkovska, V., and C, Stover. The role of properdin in murine zymosan-induced arthritis. Mol. Immunol., 2010, 47: 1458-1466. ISSN:0161-5890.

  • Stefanova, T.H., Ratcheva, I., Nikolova, N.J., Neychev, H.O. Effect of yeast superoxide dismutase treatment on some mediators of inflammation during adjuvant-induced arthritis in mice. Z Naturforsch C. 2010 Jan-Feb;65(1-2):141-7.

  • Dimitrova, P., Gyurkovska, V., Shalova, I., Saso, L., Ivanovska, N. Inhibition of zymosan-induced kidney dysfunction by tyrphostin AG-490. J. Inflam., 2009, 6, 13. ISSN:1476-9255.