ennshapkabg
 

Celebration 67 years The Stephan Angeloff Institute of Microbiology

 

Microbiologia Balkanica 2013 - 8th Balkan Congress of Microbiology, Veliko Tarnovo, Bulgaria

 

Pitagor 2012 awarded to Assoc. Prof. Andrey Tchorbanov from The Stephan Angeloff Institute of Microbiology

 

Meeting of the President of BAS prof. Nikola Sabotinov with Dr. Mark Jouan from RIIP

 

Official ceremony of Academic degrees diploma awards

 

Pitagor 2011 awarded to two researchers from The Stephan Angeloff Institute of Microbiology

 

 

Закон за развитие на академичния състав в Република България

 

 

Правилник за прилагане на Закона за развитието на академичния състав в Република България

 

 

Процедури по закона за развитие на академичния състав в Република България

 

 

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Bulgarian Academy of Sciences

 

Ministry of Education and Science

 

National Science Fund

 

Central Library of BAS

 

Union of Scientists in Bulgaria

 

European
Comission: Horizon 2020

Institut Pasteur

 

DKFZ

 

FEMS

 

PubMed Cenral

 

EURAXESS

 

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Laboratory of Experimental Immunology

 

 

Head: Associate Professor Andrey Tchorbanov, PhD

 

e-mail: tchorban@microbio.bas.bg

 

Tel: +359 2 979 63 57

 

STAFF

 

Assist. Professor Nikolina Mihaylova, PhD, mihaylova_n@microbio.bas.bg

 

Assist. Professor Kalina Nikolova-Ganeva, PhD, nikolova_k@microbio.bas.bg

 

Assist. Professor  Nikola Kerekov, nikolakerekov@gmail.com

 

Vera Gesheva, PhD student, veragesheva@gmail.com

 

Iva Ivanova, PhD student, iva_nova@abv.bg

 

Iliyan Manoylov, PhD student, iliyanmanoylov@gmail.com

 

Silvya Bradyanova, student MSc programme

 

Petroslav Chepinski, MSc student

 

Desislava Hlebarska, MSc student

 

Kiril Valentinov, student

 

Slav Slavov, student

 

Neli Delcheva, student

 

 

Contacts: +359 2 979 6348,  +359 2 979 3140, +359 2 979 6357

 

 

 

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Main Research topics


  • Autoimmunity

  • New generation of vaccines and immunoglobulin preparations

  • Acute and chronic inflammation


    Projects

     

  • NFSI – Bulgaria VU 704/07 New approach for selective suppression of autoreactive B cells by a chimeric anti-CD35 antibody” 2007-2011; Project leader A. Tchorbanov

  • NFSI – Bulgaria TK 317/07 “Generation of gene-engineered chimeric DNA molecules by recombinant technologies for specific therapy of autoimmune diseases2007-2011; PI: A. Tchorbanov

  • NFSI – Bulgaria VUH 11/07 “Creation of engineered chimeric molecules by protein nano-technology for therapy of autoimmune diseases” 2007-2011; PI: A. Tchorbanov

  • Bulgarian-Hungarian international  join project “Genetically engineered viral DNA vaccines 2010-2013; PI: A. Tchorbanov

  • NFSI – Bulgaria DO 312/08 “Suppression of allergen-specific B lymphocytes in humanized SCID mice using Chimeric protein-engineered antibodies 2008-2012; PI: A. Tchorbanov

  • NFSI – Bulgaria DRNF 02/11 “Biologic response of neoplastic and auto-immune B-cells to chimeric protein-engineered antibodies: flow cytometry analysis of apoptosis using novel cyanine nucleic acid dyes 2009-2012; PI: P. Dimitrova

  • NFSI – Bulgaria DTK 02/19 “DNA vaccines: Viral Antigen Targeting by Genetically Engineered Chimeric Molecules 2010-2015; PI: A. Tchorbanov

  • NFSI – Bulgaria DTK 02/78 “Antitumor activity of Gastropodan hemocyanins Running; 2010-2014; PI: A. Tchorbanov

  •  NFSI – Bulgaria DVU 10-250 “Functional elimination of autoreactive T cells by antibody therapy in murine and humanized SCID models of Systemic lupus erythematosus and Multiple sclerosis  2011-2015; PI: A. Tchorbanov

  • ACIP - ACTIONS CONCERTEES INTERPASTEURIENNES. „Viral Antigen Targeting by Genetically Engineered Chimeric Molecules” 2013-2015; PI: A. Tchorbanov

  • Bulgarian-Hungarian international  join project “Functional suppression  of autoreactive T cells in murine and humanized SCID models of SLE 2013-2015; PI: A. Tchorbanov



Selected  Publications



  • Nikolova K., Mihaylova N., Voynova E., Kerekov N., Gesheva V., Prechl J., Nikolova M., Tchorbanov A. Re-establishing tolerance to DNA in humanized and murine models of SLE. Autoimmun Rev 2010, 9, 499–502. ISSN: 1568-9972

  • Dimitrova I., Gesheva V., Nikolova K., Mihaylova N., Todorov T., Nikolova M. Tchorbanov A. Target silencing of disease-associated B-lymphocytes by chimeric molecules in SCID model of pristane-induced autoimmunity. Lupus 2010, 19(11),  1261-1271. ISSN: 1477-0962

  • Nikolova K., Mihaylova N., Voynova E., Tchorbanov A., Voll R., Vassilev T. Selective silencing of autoreactive B lymphocytes – following the Nature’s way. Autoimmun Rev 2010, 9, 775-779. ISSN: 1568-9972.

  • Papp K., Végh P., Tchorbanov A., Vassilev T., Erdei A.,  Prechl J. Progression of the SLE-like disease drives the appearance of complement activating IgG antibodies in MRL/lpr mice. Rheumatology 2010, 49(12), 2273-2280. ISSN: 1568-9972

  • Gesheva V., Idakieva K., Kerekov N., Nikolova K., Mihaylova N., Doumanova L., Tchorbanov A. Marine gastropod hemocyanins as adjuvants of non-conjugated bacterial and viral proteins. Fish and Shellfish Immunol 2011, 30 (1), 135-142. ISSN: 1050-4648.

 

  • Kaloyanova S., Ivanova I., Tchorbanov A., Dimitrova P., Deligeorgiev T. Synthesis of chloro-substituted analogs of Thiazole Orange - fluorophores for flow cytometric analyses. J Photochem Photobiol B: Biology 2011, 103, 215–221. ISSN: 1011-1344

  • Gesheva V., Idakieva K., Kerekov N., Nikolova K., Mihaylova N., Doumanova L., Tchorbanov A. Rapana Thomasiana hemocyanin as adjuvant for conventional vaccines. Adv Bulgarian Science 2011, 21-29. ISSN 1312-6164

  • Kerekov N., Mihaylova N., Prechl J., Tchorbanov A. Humanized SCID Mice Models of SLE. Curr Pharmaceutical Design 2011, 17 (13), 1261-1266. ISSN: 1873-4286

  • Mihaylova N., Tchorbanov A. Selective Immunotherapy by engineered chimeric molecules. Acta Facultatis Medicae Naissensis 2011, 28(1), 5-15. ISSN: 2217-2521

  • Kerekov N., Mihaylova N., Grozdev I., Todorov T., Nikolova M., Baleva M., Nikolova M., Prechl J., Erdei A., Tchorbanov A. Elimination of autoreactive B cells in humanized SCID mouse model of SLE. Eur J Immunol 2011, DOI 10.1002/eji.201141439. ISSN: 1521-4141

  • Petkova, S., Nikolova, K., Mihaylova N., Tchorbanov A. Characterization of chimeric molecules that suppress selectively autoreactive B-cells in murine models of lupus. Proceedings, Youth Scientific conference “Kliment’s days”, Sofia, 2011, ISSN: 1314 – 4960; 49-52.

  • Petkova, S., Nikolova, K., Mihaylova N., Tchorbanov A. Characterization of chimeric molecules that suppress selectively autoreactive B-cells in murine models of lupus. Proceedings, Youth Scientific conference “Kliment’s days”, Sofia, 2011, ISSN: 1314 – 4960; 49-52.

  • Mihaylova N., Tchorbanov A. New biotechnology approaches for immunotherapy of autoimmune diseases. Biotechnol Biotechnol Eq 2011, 25/4, 24-29. ISSN: 1310-2818
     

  • Gesheva V., Idakieva K., Doumanova L., Tchorbanov A.  Anti-cancer properties of Rapana thomasiana hemocyanin in experimental models in vitro and in vivo. Здраве и наука 2012, 2(5), 30-34. ISSN 1314-2674

 

  • Gesheva V., Szekeres Z., Mihaylova N., Dimitrova I., Nikolova M., Erdei A., Prechl J., Tchorbanov A. Generation of gene-engineered chimeric DNA molecules for specific therapy of autoimmune diseases. Human Gene Therapy Methods 2012, 23(6): 357-365. ISSN: 1557-7422

 

  • Nikolova, K., Kaloyanova, S., Mihaylova, N., Stoitsova, S., Chausheva, S., Vasilev, A., Lesev, N., Dimitrova, P., Deligeorgiev, T., Tchorbanov, A. New fluorogenic dyes for analysis of cellular processes by flow cytometry and confocal microscopy. J Photochem Photobiol B: Biology 2013, 129: 125-134. DOI 10.1016/j.photobiol.2013.10.010. ISSN: 1011-1344

  • Djoumerska-Alexieva I., Manoylov I., Dimitrov J., Tchorbanov A. Serum or breast milk immunoglobulins mask the self-reactivity of human natural IgG antibodies. APMIS 2014, 122: 329–340; DOI 10.1111/apm.12149. ISSN: 1600-0463

  • Kerekov N., Michova A., Muhtarova M., Nikolov G., Mihaylova N., Petrunov B., Nikolova M., Tchorbanov A. Suppression of allergen-specific B lymphocytes by chimeric protein-engineered antibodies. IMBIO 2014, 219(1): 45–52; DOI 10.1016/j.imbio.2013.07.009. ISSN: 0171-2985

  • Gesheva V., Kerekov N., Nikolova, K., Mihaylova N., Todorov T., Nikolova M., Tchorbanov A. Suppression of dsDNA-specific B Lymphocytes reduces disease symptoms in SCID model of mouse lupus. Autoimmunity 2014, 6;47(3):162-72; DOI: 10.3109/08916934.2014.883502. ISSN: 1568-9972

  • Kerekov N., Ivanova I., Mihaylova N., Nikolova M., Prechl J., Tchorbanov A. Built-in adjuvanticity of Genetically and Protein Engineered Chimeric Molecules for Targeting of Influenza A peptide epitopes. Immunol Research 2014, 60(1), 23-34; DOI 10.1007/s12026-014-8489-0. ISSN: 0257-277X

  • Birner P., Pusch S., Christov C., Mihaylova S., Toumangelova-Uzeir K., Natchev S., Schoppmann S.F., Tchorbanov A., Wesseling P., Streubel B., Tuettenberg J., Guentchev M. Mutant IDH1 inhibits PI3K/Akt signaling in human glioma. Cancer 2014, 120 (16), 2440-2447; DOI: 10.1002/cncr.28732. ISSN: 1097-0142

  • Gesheva V., Chausheva S., Mihaylova  N., Manoylov I., Doumanova L., Idakieva K., Tchorbanov A. Anti-cancer properties of gastropodan hemocyanins in murine model of colon carcinoma. BMC Immunology 2014, 15:34, DOI: 10.1186/s12865-014-0034-3. ISSN: 1471-2172