Head: Corresponding Member of BAS, Professor Atanas Pavlov, DSc
Contacts: +359 2 898 690 599
e-mail: at_pavlov@yahoo.com
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STAFF: |
Assoc. Professor Dr. Dora Beshkova +359 2 642 430 beshkova@yahoo.com
Assoc. Professor Dr. Milen Georgiev +359 2 642 430 milen.georgiev@mailbox.tu-dresden.de
Assoc. Professor Dr. Vasil Georgiev +359 2 642 430 vasgeorgiev@gmail.com
Assist. Prof. Dr. Snezhana Rusinova-Videva +359 2 642 430 jrusinova@abv.bg
Assist. Prof. Dr. Andrey Marchev +359 2 642 430 andrey.marchev@yahoo.com
Assist. Prof. Tsvetanka Teneva-Angelova +359 2 642 430 teneva.tsvetanka@yahoo.com
Assist. Prof. Dr. Katia Yoanidu +359 2 642 430; 088408896 katqioanidu@abv.bg
Microbiologist Katerina Georgieva +359 2 642 430 zvezdolet@abv.bg
Microbiologist Tatyana Gocheva +359 2 642 430 katia_ag@abv.bg
Technologist Elka Genova +359 2 642 430 elisgen@yahoo.com
Technician Ivanka Koycheva +359 2 642 430 vkoy4eva@abv.bg
Technician Vasilka Ushterova +359 2 642 430
| CURENT RESEARCH TOPICS: |
- Plant secondary metabolism (iridoids, phenylethanoids, phenylpropanoids, flavonoids, terpenoids and essential oils)
- NMR-based metabolomics and comprehensive metabolite profiling
- Natural product chemistry and leads discovery
- Agrobacterium rhizogenes-mediated plant genetic transformation
- Bioreactor systems for plant cells and bioengineering
- Biologically active substances from plant in vitro systems
- Biologically active substances by Antarctic yeasts
- Isolation, identification and characterization of lactic acid bacteria strains from medical plants (Panax ginsengA. Meyer, Geranium sanguineum L., Hypericum perforatum L. and four Salvia species) with high biological activities. Formation of multifunctional starter cultures for production of fermented foods with high biological value and expressed health effect.
| PROJECTS:. |
On-going projects:
- Establishment of a center of plant systems biology and biotechnology for the translation of fundamental research into sustainable bio-based technologies in Bulgaria.
- Duration: 2017 – 2024
- PI for IMicB-BAS: Assoc. Prof. Georgiev, PhD
- Funding organization: European Union, H2020-Widespread-2016-2017/H2020-WIDESPREAD-01-2016-2017-TeamingPhase2 (Grant number: 739582-PlantaSYST)
- Collaborators: Institute of Molecular Biology and Biotechnology (IMBB), Bulgaria; Maritsa Vegetable Crops Research Institute (MVCRI); Universitaet Potsdam (UP), Germany; Max-Plank-Gesellschaft zur Forderung der wissenschaften E. V. (MPG), Germany
- Sustainable valorization of by-products from medicinal and aromatic plants industry into value-added products.
- PI for IMicB-BAS: Assoc. Prof. Georgiev, PhD
- Funding organization: National Authority for Innovation and Scientific Research and Ministry of European Funds, Romania (Grant number: 89/09.09.2016)
- Biotechnological platform for sustainable production of pharmaceutically relevant metabolites from golden root.
- Duration: 2016 – 2017
- PI: Senior Assist. Prof. Andrey Marchev, PhD
- Funding organization: Bulgarian Academy of Sciences “programme for supporting young scientists in BAS” (Grant № DFNP-58)
- Rational platform for halogenation of high-value phenylethanoid glycosides from plant root culture.
- Duration: 2014 – 2017
- PI: Assoc. Prof. Milen Georgiev, PhD
- Funding organization: Bulgarian National Science Fund and DAAD, Germany (Grant № DNTS-01/8)
- Collaborators: Institute für Botanik, Technische Universitaet Dresden, Germany
- Rational platform for sustainable production of pharmaceutically relevant molecules from plants and their in vitro culture.
- Duration: 2014 – 2017
- PI for IMcB-BAS: Assoc. Prof. Milen Georgiev, PhD
- Funding organization: Bulgarian National Science Fund (Grant № DFNI B-02/14)
- Metabolic profiling and antineoplastic potential of Antarctic yeasts (DFNP-60/ 27.04.2016), Duration:2016-2017
- Project Leader: Senior Assist. Snezhana Rusinova-Videva, PhD
- Funding organization: Bulgarian Academy of Sciences (Funding program for young scientists in Bulgarian Academy of Sciences)
- Preparation of fermented dairy products with enhanced biological value.
- Duration: 2016 – 2017 (1 year).
- Project Leader: Assist. Tsvetanka Teneva-Angelova.
- Funding organization: Bulgarian Academy of Sciences (Funding program for young scientists in Bulgarian Academy of Sciences)
- Rational design of new bioprocesses for the sustainable production of plant secondary metabolites used in cancer treatment and prevention.
- PI for IMicB-BAS: Assoc. Prof. Milen Georgiev, PhD
- Funding organization: MINECO (Spanish Ministry of Economy and Competitively)
- Complex assessment of donor genotypes of Bulgarian tomato cultivars and approach of creation of new cultivars with improved content of antioxidants and improved teste quolity плодовете
- Duration: 2012 to present
- Project Leader for IMicB-BAS: Prof. Atanas Pavlov
- Funding organization: Bulgarian National Science Fund (ДФНИ – Б01/16 – 2012 г.)
- Collaborators: Agricultural University, Maritsa Vegetable Crops Research Institute
- Application of the OMICS technologies to revealed health potential of Bulgarian honey
- Duration: 2012 to present
- Project Leader for IMicB-BAS: Prof. Atanas Pavlov
- Funding organization: Bulgarian National Science Fund (ДФНИ – Б01/31 – 2012 г.)
- Collaborators: University of Sofia, Institute of Organic Chemistry with Center of Phytochemistry – BAS
Completed projects:
- Establishment of centre of plant systems biology and biotechnology for the translation of fundamental research into sustainable bio-based technologies in Bulgaria.
- Duration: 2015 – 2016
- PI for IMicB-BAS: Assoc. Prof. Georgiev, PhD
- Funding organization: European Union, H2020-Widespread-2014-1 (Grant number: 664621-PlantaSYST)
- Collaborators: Institute of Molecular Biology and Biotechnology (IMBB), Bulgaria; Maritsa Vegetable Crops Research Institute (MVCRI); Universitaet Potsdam (UP), Germany; Max-Plank-Gesellschaft zur Forderung der wissenschaften E. V. (MPG), Germany
- Innovative approaches for obtaining and analysis of the biological activity of extracts from the fruits of jujube (Ziziphus jujuba Rhamnaceae).
- Duration: 2015 – 2016
- PI for IMicB-BAS: Senior assist. Prof. Andrey Marchev, PhD
- Funding organization: Fund „Science“of The University of Food Technologies – Plovdiv, Bulgaria (Grant № N 9/15-H)
- Collaborators: University of Food Technologies – Plovdiv
- Biosynthesis of exopolysaccharides by extremophilic microorganisms (DFNI B02/46)
- Duration: 2009-2013
- Project leader: Prof. Dr Serafim Vlaev
- Funding organization: Bulgarian National science Fund
- Colabarations: Institute of Chemical Engineering, University of Food Technology-Plovdiv.
- Investigation of plant in vitro systems of Salvia species with different ploidy levels
- Duration: 2010 – 2013 г.
- Project leader: Prof. Atanas Pavlov
- Funding organization: DAAD and Bulgarian National Science Fund (ДНТС 02/5-2010 г.)
- Collaborations: TU Dresden
| SELECTED PUBLICATIONS: |
- Marchev, A., Dimitrova, P., Koycheva, I., Georgiev, M. Altered expression of TRAIL on mouse T cells via ERK phosphorylation by Rhodiola rosea L. and its marker compounds. Food and Chemical Toxicology, 2017, DOI: 10.1016/j.fct.2017.02.009. IF:3.584
- Alipieva, K., Simova, S., Zahmanov, G., Zhou, S., Wolfender, J-L., Georgiev, M. New tetraacetylated iridoid glycosides from Sambucus ebulus L. leaves. Phytochemistry Letters, 2017, DOI: 10.1016/j.phytol.2017.01.003. IF:1.353
- Marchev, A., Aveva, I., Koycheva, I., Georgiev, M. Phytochemical variations of Rhodiola rosea L. wild-grown in Bulgaria. Phytochemistry Letters, 2016, DOI: 10.1016/j.phytol.2016.12.030. IF:1.353
- Georgiev, M., Radziszewska, A., Neumann, M., Marchev, A., Alipieva, K., Ludwig-Müller J. Metabolic alterations of Verbascum nigrum L. plants and SAArT transformed roots as revealed by NMR-based metabolomics. Plant Cell, Tissue and Organ Culture, 123, 2015, 349-356. IF:2.125
- Georgieva, L., Ivanov, I., Marchev, A., Aneva, I., Denev, P., Georgiev, V., Pavlov, A. Protopine production by Fumaria cell suspension cultures: Effect of Light. Applied Biochemistry and Biotechnology, 176, 1, 2015, 287-300
- Georgiev, V., Ivanov, I., Berkov, S., Pavlov, A. Temporary immersion systems for Amaryllidaceae alkaloids biosynthesis by Pancratium maritimum L. shoot culture. Journal of Plant Biochemistry and Biotechnology, 23, 4, 2014, 389-398
- Georgiev, V., Schumann, A., Pavlov, A., Bley, T. Temporary immersion systems in plant biotechnology. Engineering in Life Sciences, 14, 6, 2014, 607-621.
- Vlaev, S, Pavlova, K, Rusinova-Videva, S, Georgieva, K, Georgiev, D. Agitation effects and Kinetic constants of exoglucomannan production by Antarctic yeast strain in a stirred tank bioreactor. Chemistry and Biochemistry Engeneering Quarterly, 30, 4, 2016, 393-400, ISI IF 0.675
- Rusinova-Videva, S, Dimitrova, S, Georgieva, K, Katsarova, M, Pavlova, K. Effect of Zn2+, Cu2+ and Fe2+ ions for accumulation of ergosterol, β–carotene and coenzyme Q10 by Antarctic yeast strain Sporobolomyces salmonicolor AL1. Comptes rendus de l’Académie bulgare des Sciences, 69, 8, 2016, 1003-1010, ISI IF 0.280
- Vlaev, S, Rusinova-Videva, S, Pavlova, K, Kuncheva, M, Panchev, I, Dobreva, S. Submerged culture process for biomass and exopolysaccharide production by Antarctic yeast: some engineering considerations. Appllied Microbiology and Biotechnology 97, 12, 2013, 5303-5313, ISI IF 3.811
- Kuncheva, M, Panchev, I, Pavlova, K, Rusinova-Videva, S, Georgieva, K, Dimitrova, S. Functional characteristics of an exopolysaccharide from Antarctic yeast strain Cryptococcus laurentii AL62. Biotechnology and Biotechnological Equipment 27, 5, 2013, 4098-4102. ISI IF 0.622
- Teneva-Angelova, Ts., Hristova, I., Pavlov, A., Beshkova, D. Lactic Acid Bacteria – From Nature through Food to Health. Handbook of food bioengineering, 14, Elsevier, in press: 2016
- Teneva-Angelova, Ts., Beshkova, D. Non-traditional sources for isolation of lactic acid bacteria. Annals of Microbiology, 66, 3, Springer-Verlag, 2016, DOI:10.1007/s13213-015-1127-9, 449-459. SJR:0.39, ISI IF 1.232
- Teneva-Angelova, Ts., Beshkova, D. Genus Salvia – ecosystem for isolation of lactic acid bacteria. Journal of Microbiology, Biotechnology and Food Sciences, 5, 2, 2015, ISSN:1338-5178, 103-108
- Teneva-Angelova, Ts., Beshkova, D. Resistance profile of plant-derived lactic acid bacteria against herb extracts. Scientific Bulletin. Series F. Biotechnologies, XIX, 2015, ISSN:2285-1364, 109-111oanidu K., Boyanova P., Panayotov P. Exopolysaccharide influence’s on acid gel formation. Agricultural Science and Technology, ISSN 1313-8820, in press: 2017
| ANY RELEVANT IMPORTANT INFORMATION: |
2015: Assoc. Prof. Dr. Milen Georgiev – Pythagoras award by the Bulgarian Government for outstanding scientist in biotechnology
2011: Assoc. Prof. Dr. Milen Georgiev – Pythagoras award by the Bulgarian Government for the best outstanding young scientist (under age of 35 years)