{"id":1179,"date":"2017-11-09T19:54:05","date_gmt":"2017-11-09T16:54:05","guid":{"rendered":"http:\/\/microbio.bas.bg\/wordpress\/?page_id=1179"},"modified":"2020-11-25T16:51:00","modified_gmt":"2020-11-25T13:51:00","slug":"laboratorya-molekulyarna-biologya-na-mikobakterii","status":"publish","type":"page","link":"https:\/\/microbio.bas.bg\/wordpress\/index.php\/struktura\/nauchni-zvena-2\/departament-infektsiozna-mikrobiologiya\/laboratorya-molekulyarna-biologya-na-mikobakterii\/","title":{"rendered":"\u041b\u0410\u0411\u041e\u0420\u0410\u0422\u041e\u0420\u0418\u042f \u041c\u041e\u041b\u0415\u041a\u0423\u041b\u042f\u0420\u041d\u0410 \u0411\u0418\u041e\u041b\u041e\u0413\u0418\u042f \u041d\u0410 \u041c\u0418\u041a\u041e\u0411\u0410\u041a\u0422\u0415\u0420\u0418\u0418"},"content":{"rendered":"

\u0420\u044a\u043a\u043e\u0432\u043e\u0434\u0438\u0442\u0435\u043b:\u00a0 \u0414\u043e\u0446. \u0434-\u0440 \u041d\u0430\u0434\u044f \u041c\u0430\u0440\u043a\u043e\u0432\u0430, \u0434\u0431<\/span><\/p>\n

\u0422\u0435\u043b.: +359 2 979 31 61<\/span><\/p>\n

E-mail: nadya.markova@gmail.com<\/a><\/span><\/p>\n

Author ID Scopus (ScienceDirect): 7006844985<\/span>
\nhttps:\/\/www.scopus.com\/authid\/detail.uri?authorId=7006844985<\/span><\/a>
\nhttps:\/\/www.researchgate.net\/profile\/Nadya_Markova<\/span><\/a>
\nhttps:\/\/scholar.google.com\/citations?user=D5NneqEAAAAJ&hl=bg&oi=ao<\/span><\/a><\/p>\n

 <\/p>\n\n\n\n
\u0421\u042a\u0421\u0422\u0410\u0412:<\/span><\/strong><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u0414\u043e\u0446. \u0434-\u0440 \u0412\u0438\u043e\u043b\u0435\u0442\u0430 \u0412\u044a\u043b\u0447\u0435\u0432\u0430<\/span><\/p>\n

\u0422\u0435\u043b.: +359 2 979 31 61<\/span><\/p>\n

E-mail: violeta_valcheva@mail.bg<\/a><\/span><\/p>\n

Author ID Scopus (ScienceDirect): 14061470900, Valcheva, Violeta<\/span>
\nhttps:\/\/www.scopus.com\/authid\/detail.uri?authorId=14061470900<\/span><\/a>
\nhttps:\/\/www.researchgate.net\/profile\/Violeta_Valcheva\/publications<\/span><\/a>
\nhttps:\/\/scholar.google.bg\/scholar?hl=en&q=violeta+valcheva&btnG=&as_sdt=1%2C5&as_sdtp=<\/span><\/a><\/p>\n

 <\/p>\n

\u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438 \u043b\u0430\u0431\u043e\u0440\u0430\u043d\u0442 \u0410\u043b\u0431\u0435\u043d\u0430 \u0427\u0435\u0440\u043d\u0435\u0432\u0430<\/span><\/p>\n

\u0422\u0435\u043b.: +359 2 979 31 61<\/span><\/p>\n

E-mail: albenacherneva@abv.bg<\/a><\/span><\/p>\n

 <\/p>\n\n\n\n
\u041e\u0421\u041d\u041e\u0412\u041d\u0418 \u0422\u0415\u041c\u0418 \u041d\u0410 \u0418\u0417\u0421\u041b\u0415\u0414\u0412\u0410\u041d\u0418\u042f\u0422\u0410:<\/strong><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u2981 \u041c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u0430 \u0435\u043f\u0438\u0434\u0435\u043c\u0438\u043e\u043b\u043e\u0433\u0438\u044f, \u0444\u0438\u043b\u043e\u0433\u0435\u043d\u0435\u0442\u0438\u043a\u0430 \u0438 \u0435\u0432\u043e\u043b\u044e\u0446\u0438\u044f \u043d\u0430 \u043c\u0438\u043a\u043e\u0431\u0430\u043a\u0442\u0435\u0440\u0438\u0438 (\u0414\u041d\u041a \u0438\u0437\u043e\u043b\u0430\u0442\u0438 \u043e\u0442 Mycobacterium tuberculosis<\/em> \u043a\u043e\u043c\u043f\u043b\u0435\u043a\u0441 (Mycobacterium tuberculosis<\/em> \u0438 Mycobacterium bovis<\/em>).<\/span><\/p>\n

\u2981 \u0411\u0438\u043e\u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0442\u0438\u0447\u043d\u0438 \u043f\u043e\u0434\u0445\u043e\u0434\u0438 \u0437\u0430 \u0430\u043d\u0430\u043b\u0438\u0437 \u043d\u0430 \u043c\u0438\u043a\u043e\u0431\u0430\u043a\u0442\u0435\u0440\u0438\u0438.<\/span><\/p>\n

\u2981 \u0421\u043a\u0440\u0438\u043d\u0438\u043d\u0433 \u043d\u0430 \u043d\u043e\u0432\u043e\u0441\u0438\u043d\u0442\u0435\u0437\u0438\u0440\u0430\u043d\u0438 \u0441\u044a\u0435\u0434\u0438\u043d\u0435\u043d\u0438\u044f \u0437\u0430 \u0442\u044f\u0445\u043d\u0430\u0442\u0430 in vitro<\/em> \u0430\u043d\u0442\u0438\u043c\u0438\u043a\u043e\u0431\u0430\u043a\u0442\u0435\u0440\u0438\u0430\u043b\u043d\u0430 \u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442.<\/span><\/p>\n

\u2981 \u041c\u0438\u043a\u043e\u0431\u0430\u043a\u0442\u0435\u0440\u0438\u0438 \u0438 \u041b-\u0442\u0440\u0430\u043d\u0441\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f, \u043b\u0430\u0442\u0435\u043d\u0442\u043d\u0430 \u0442\u0443\u0431\u0435\u0440\u043a\u0443\u043b\u043e\u0437\u0430, \u0411\u0426\u0416 \u0432\u0430\u043a\u0441\u0438\u043d\u0430, \u043f\u043b\u0430\u0446\u0435\u043d\u0442\u0430\u0440\u0435\u043d \u043c\u0438\u043a\u0440\u043e\u0431\u0438\u043e\u043c \u0438 \u0438\u043c\u0443\u043d\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u043d \u0444\u0435\u043d\u043e\u043c\u0435\u043d \u043f\u043e \u0432\u0440\u0435\u043c\u0435 \u043d\u0430 \u0431\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0441\u0442.<\/span><\/p>\n

\u2981 \u0420\u0430\u0437\u0440\u0430\u0431\u043e\u0442\u0432\u0430\u043d\u0435 \u043d\u0430 \u043c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u043e-\u0431\u0438\u043e\u043b\u043e\u0433\u0438\u0447\u043d\u0438 \u043f\u043e\u0434\u0445\u043e\u0434\u0438 \u0437\u0430 \u0434\u0435\u0442\u0435\u043a\u0446\u0438\u044f \u0438 \u0438\u0434\u0435\u043d\u0442\u0438\u0444\u0438\u043a\u0430\u0446\u0438\u044f \u043d\u0430 \u043c\u0438\u043a\u043e\u0431\u0430\u043a\u0442\u0435\u0440\u0438\u0430\u043b\u043d\u0438 \u041b-\u0444\u043e\u0440\u043c\u0438.<\/span><\/p>\n

\u2981 \u041c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u0438 \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u043c\u0438 \u043d\u0430 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u0430 \u0440\u0435\u0437\u0438\u0441\u0442\u0435\u043d\u0442\u043d\u043e\u0441\u0442 \u0438 \u0442\u043e\u043b\u0435\u0440\u0430\u043d\u0442\u043d\u043e\u0441\u0442 \u043f\u0440\u0438 \u043c\u0438\u043a\u043e\u0431\u0430\u043a\u0442\u0435\u0440\u0438\u0438\u0442\u0435.<\/span><\/p>\n

 <\/p>\n\n\n\n
\u041f\u041e\u0414\u0411\u0420\u0410\u041d\u0418 \u041f\u0423\u0411\u041b\u0418\u041a\u0410\u0426\u0418\u0418:\u00a0\u00a0<\/strong><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Valcheva V.<\/b>, Savova-Lalkovska T., Vyazovaya A., Dimitrova A. <\/span>Bonovska M.<\/b>,<\/span> Najdenski H<\/b>. First insight into phylogeography of <\/span>Mycobacterium bovis<\/span><\/i> and <\/span>M.caprae<\/span><\/i> from cattle in Bulgaria, <\/span>Infection, Genetics and Evolution<\/span><\/i>, <\/span>2020<\/b>, 81: 104240 doi: 10.1016\/j.meegid.2020.104240 <\/span>IF:2.611 Q2<\/b><\/span><\/p>\n

\u2981 Savova, T., Petrova, R., <\/span>Valcheva, V.<\/b>, <\/span>Bonovska, M.<\/b>, <\/span>Najdenski, H<\/b>. Isolation of Mycobacterium avium subsp. paratuberculosis from mouflon in Bulgaria. <\/span>Russian Journal of Infection and Immunity<\/span><\/i>, <\/span>2019<\/b>, 9(5-6): 665-670. doi: 10.15789\/2220-7619-2019-5-6-665-670 <\/span>SJR 0,13, Q4<\/b><\/span><\/p>\n

\u2981 <\/span>Bonovska M<\/b>., Savova T., Petrova R., <\/span>Valcheva V.<\/b>, <\/span>Najdenski H<\/b>. Cases of paratuberculosis in deer in Bulgaria. <\/span>Comptes Rendus de Lacademie Bulgare des Sciences<\/span><\/i>, <\/span>2019<\/b>, 72 (3): 422-428, doi:10.7546\/CRABS.2019.03.18,<\/span> IF: 0.321, Q2<\/b><\/span><\/p>\n

\u2981 Yanev, S., Stoyanova, T., <\/span>Valcheva V.<\/b>, De Montellano, O. Xanthates: Metabolism by Flavoprotein-Containing Monooxygenases and Antimycobacterial Activity. <\/span>Drug Metabolism and Disposition<\/span><\/i>, <\/span>2018<\/b>. 46(8), 1091-1095. DOI:10.1124\/dmd.118.081984, 1091-1095 IF:3.64 \u00a0 Q1<\/span><\/span><\/p>\n

\u00a0\u2981 Philipova, I., <\/span>Valcheva, V.<\/b>, Mihaylova, R., Mateeva, M., Doytchinova, I. and Stavrakov, G., Synthetic piperine amide analogues with antimycobacterial activity. Chem biology & drug design. <\/span>2017<\/b>. doi: 10.1111\/cbdd.13140 <\/span>IF:2.396 Q1<\/b>\u00a0<\/span><\/span><\/p>\n

\u2981 Angelova, V., <\/span>Valcheva, V.<\/b>, Pencheva, T., Voynikov, Y., Vassilev, N., Mihaylova, R., Momekov, G., Shivachev, B. Synthesis, antimycobacterial activity and docking study of 2-aroyl-[1] benzopyrano [4, 3-c] pyrazol-4 (1H)-one derivatives and related hydrazide-hydrazones. <\/span>Bioorg Med Chem Lett<\/span><\/i>, <\/span>2017<\/b>. 27 (13): 2996-3002. doi: 10.1016\/j.bmcl.2017.05.011 <\/span>IF:2.454 Q1 25\u0442<\/b><\/span><\/p>\n

\u2981 Mokrousov I, Vyazovaya A, Iwamoto T, Skiba Y, Pole I, Zhdanova S, Arikawa K, Sinkov V, Umpeleva T, <\/span>Valcheva V.<\/b>, Alvarez Figueroa M, Ranka R, Jansone I, Ogarkov O, Zhuravlev V, Narvskaya O. <\/span>Latin-American-Mediterranean lineage of Mycobacterium tuberculosis: Human traces across pathogen’s phylogeography<\/span><\/a>. <\/span>Molecular Phylogenetics and Evolution<\/span><\/i>, <\/span>2016<\/b>, 99:133-143. doi: 10.1016\/j.ympev.2016.03.020. <\/span>IF 3.916 Q1\u00a0<\/b><\/span><\/p>\n

\u2981 Mokrousov, I., Chernyaeva, E., Vyazovaya, A., Skiba, Y., Solovieva, N., <\/span>Valcheva, V.<\/b>, Levina, K., Malakhova, N., Jiao, W.W., Gomes, L.L. and Suffys, P.N., A rapid assay for detection of the epidemiologically important Central Asian\/Russian strain of the Mycobacterium tuberculosis Beijing genotype. J <\/span>Clin Microbiol.<\/span><\/i> 2017<\/b>. pii: JCM.01551-17. doi: 10.1128\/JCM.01551-17\u00a0 <\/span>IF:2.44 Q1<\/b><\/span><\/p>\n

\u2981 Stavrakov, G., <\/span>Valcheva, V.<\/b>, Voynikov, Y., Philipova, I., Atanasova, M., Konstantinov, S., Doytchinova, I. Design, Synthesis, and Antimycobacterial Activity of Novel Theophylline\u20107\u2010Acetic Acid Derivatives with Amino Acid Moieties. <\/span>Chem biology & drug design<\/span><\/i>. <\/span>2016<\/b>. 87(3):335-41. doi: 10.1111\/cbdd.12676 <\/span>IF 2.48 Q1<\/b><\/span><\/p>\n

\u2981 <\/span>Valcheva V.<\/b>, Rastogi, N., Mokrousov, I. Prevalence of Latin-American-Mediterranean genetic family in population structure of Mycobacterium tuberculosis in Bulgaria. <\/span>International Journal of mycobacteriology<\/span><\/i>, <\/span>2015<\/b>, 4(1): 22-23<\/span><\/span><\/p>\n

\u00a0doi:10.1016\/j.ijmyco.2014.10.044 <\/span>IF 0,167 Q3<\/b><\/span><\/p>\n

\u2981 <\/span>Markova N.<\/b>, Slavchev G., Djerov L., Nikolov A., Dimova T. Mycobacterial L-forms are found in cord blood: A potential vertical transmission of BCG from vaccinated mothers. <\/span>Human Vaccines & Immunotherapeutics<\/span><\/i>. <\/span>2016<\/b>, 12: 2565-2571.<\/span> http:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/21645515.2016.1193658?journalCode=khvi20<\/span><\/a><\/span><\/p>\n

\u2981 <\/span>Markova N.<\/b>, Slavchev G, Michailova L. Presence of mycobacterial L-forms in human blood: Challenge of BCG vaccination. <\/span>Human Vaccines & Immunotherapeutics<\/span><\/i>. <\/span>2015<\/b>, 11: 1192-200. <\/span>\u00a0<\/span>https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22495116<\/span><\/a><\/span><\/p>\n

 <\/p>\n\n\n\n
\u041f\u041e\u0421\u0422\u0418\u0416\u0415\u041d\u0418\u042f:<\/strong><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u2981 \u041f\u0440\u043e\u0432\u0435\u0434\u0435\u043d\u043e \u0435 \u043f\u044a\u0440\u0432\u043e\u0442\u043e \u0437\u0430 \u0411\u044a\u043b\u0433\u0430\u0440\u0438\u044f \u0432 \u043e\u0431\u043b\u0430\u0441\u0442\u0442\u0430 \u043d\u0430 \u0436\u0438\u0432\u043e\u0442\u043d\u043e\u0432\u044a\u0434\u0441\u0442\u0432\u043e\u0442\u043e \u043c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u043e \u0433\u0435\u043d\u0435\u0442\u0438\u0447\u043d\u043e \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0435, \u043e\u0442\u043d\u043e\u0441\u043d\u043e \u0433\u0435\u043d\u0435\u0442\u0438\u0447\u043d\u043e\u0442\u043e \u0440\u0430\u0437\u043d\u043e\u043e\u0431\u0440\u0430\u0437\u0438\u0435 \u043d\u0430 \u0446\u0438\u0440\u043a\u0443\u043b\u0438\u0440\u0430\u0449\u0438\u0442\u0435 \u0432 \u0411\u044a\u043b\u0433\u0430\u0440\u0438\u044f \u0449\u0430\u043c\u043e\u0432\u0435 Mycobacterium bovis, \u043a\u043e\u0435\u0442\u043e \u0449\u0435 \u043f\u043e\u0434\u043f\u043e\u043c\u043e\u0433\u043d\u0435 \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u0435\u0442\u043e \u043d\u0430 \u043c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u0430\u0442\u0430 \u0435\u043f\u0438\u0434\u0435\u043c\u0438\u043e\u043b\u043e\u0433\u0438\u044f \u0432\u044a\u0432 \u0432\u0435\u0442\u0435\u0440\u0438\u043d\u0430\u0440\u043d\u0430\u0442\u0430 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0430. \u0414\u043e\u0431\u0430\u0432\u0435\u043d\u0430 \u0435 \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u044f \u043a\u044a\u043c \u0441\u0432\u0435\u0442\u043e\u0432\u043d\u0430\u0442\u0430 \u0431\u0430\u0437\u0430 \u0434\u0430\u043d\u043d\u0438 \u0437\u0430 \u0431\u044a\u043b\u0433\u0430\u0440\u0441\u043a\u0438\u0442\u0435 Mycobacterium bovis \u0449\u0430\u043c\u043e\u0432\u0435.<\/span><\/p>\n

\u2981 \u0417\u0430 \u043f\u044a\u0440\u0432\u0438 \u043f\u044a\u0442 \u0435 \u0443\u0441\u0442\u0430\u043d\u043e\u0432\u0435\u043d\u0430 \u0446\u0438\u0440\u043a\u0443\u043b\u0430\u0446\u0438\u044f\u0442\u0430 \u043d\u0430 \u0449\u0430\u043c\u043e\u0432\u0435 Mycobacterium caprae \u0432 \u0441\u0442\u0440\u0430\u043d\u0430\u0442\u0430 \u043d\u0438. \u0417\u0430\u0441\u0438\u043b\u0435\u043d\u0430\u0442\u0430 \u0442\u044a\u0440\u0433\u043e\u0432\u0438\u044f \u043d\u0430 \u0432\u043d\u043e\u0441 \u0438 \u0438\u0437\u043d\u043e\u0441 \u043d\u0430 \u0436\u0438\u0432\u043e\u0442\u043d\u0438 \u0432 \u0438 \u0438\u0437\u0432\u044a\u043d \u0411\u044a\u043b\u0433\u0430\u0440\u0438\u044f \u0432\u0435\u0440\u043e\u044f\u0442\u043d\u043e \u0435 \u0434\u043e\u0432\u0435\u043b\u0430 \u0434\u043e \u043f\u043e\u044f\u0432\u0430\u0442\u0430 \u043c\u0443 \u0432 \u0441\u0442\u0440\u0430\u043d\u0430\u0442\u0430 \u043d\u0438 \u043f\u0440\u0435\u0437 \u043f\u043e\u0441\u043b\u0435\u0434\u043d\u0438\u0442\u0435 \u0433\u043e\u0434\u0438\u043d\u0438.<\/span><\/p>\n

\u2981 \u0417\u0430 \u043f\u044a\u0440\u0432\u0438 \u043f\u044a\u0442 \u043e\u0442 40 \u0433. \u0435 \u0438\u0437\u0432\u044a\u0440\u0448\u0435\u043d\u043e \u0437\u0430\u0434\u044a\u043b\u0431\u043e\u0447\u0435\u043d\u043e \u043a\u043e\u043c\u043f\u043b\u0435\u043a\u0441\u043d\u043e \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0435 \u0437\u0430 \u043d\u0430\u043b\u0438\u0447\u0438\u0435 \u043d\u0430 \u043f\u0430\u0440\u0430\u0442\u0443\u0431\u0435\u0440\u043a\u0443\u043b\u043e\u0437\u0430 \u043f\u0440\u0438 \u0435\u043b\u0435\u043d\u0438 \u0438 \u043c\u0443\u0444\u043b\u043e\u043d\u0438 \u0441\u0432\u043e\u0431\u043e\u0434\u043d\u043e \u043e\u0442\u0433\u043b\u0435\u0436\u0434\u0430\u043d\u0438 \u0432 \u043b\u043e\u0432\u043d\u0438 \u0441\u0442\u043e\u043f\u0430\u043d\u0441\u0442\u0432\u0430 \u0432 \u0411\u044a\u043b\u0433\u0430\u0440\u0438\u044f. \u0423\u0441\u0442\u0430\u043d\u043e\u0432\u0435\u043d\u0438\u0442\u0435 \u0437\u0430 \u043f\u0430\u0440\u0430\u0442\u0443\u0431\u0435\u0440\u043a\u0443\u043b\u043e\u0437\u0430\u0442\u0430 \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u043d\u0438 \u043f\u0430\u0442\u043e\u0430\u043d\u0430\u0442\u043e\u043c\u0438\u0447\u043d\u0438 \u0438\u0437\u043c\u0435\u043d\u0435\u043d\u0438\u044f \u0441\u0430 \u043f\u043e\u0442\u0432\u044a\u0440\u0434\u0435\u043d\u0438 \u043f\u0440\u0438 \u043f\u0440\u043e\u0432\u0435\u0434\u0435\u043d\u0438\u0442\u0435 \u0445\u0438\u0441\u0442\u043e\u043b\u043e\u0433\u0438\u0447\u043d\u0438, \u043c\u0438\u043a\u0440\u043e\u0431\u0438\u043e\u043b\u043e\u0433\u0438\u0447\u043d\u0438 \u0438 \u043c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u043e- \u0433\u0435\u043d\u0435\u0442\u0438\u0447\u043d\u0438 \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0438\u044f.<\/span><\/p>\n

\u2981 \u0421\u0438\u043d\u0442\u0435\u0437\u0438\u0440\u0430\u043d\u0438 \u0441\u0430 \u043d\u0430\u0434 200 \u043d\u043e\u0432\u0438 \u0440\u0430\u0437\u043d\u043e\u043e\u0431\u0440\u0430\u0437\u043d\u0438 \u0441\u0442\u0440\u0443\u043a\u0442\u0443\u0440\u0438, \u0441\u0440\u0435\u0434 \u043a\u043e\u0438\u0442\u043e \u043f\u043e\u0432\u0435\u0447\u0435 \u043e\u0442 50 \u0445\u0438\u0440\u0430\u043b\u043d\u0438 \u0441\u044a\u0435\u0434\u0438\u043d\u0435\u043d\u0438\u044f, \u043f\u0440\u043e\u0438\u0437\u0432\u043e\u0434\u043d\u0438 \u043d\u0430 \u043f\u0440\u0438\u0440\u043e\u0434\u043d\u0438\u0442\u0435 \u0442\u0435\u0440\u043f\u0435\u043d\u043e\u0438\u0434\u0438 (+)-\u043a\u0430\u043c\u0444\u043e\u0440 \u0438 (-)-\u0444\u0435\u043d\u0445\u043e\u043d. \u041d\u0430\u043f\u0440\u0430\u0432\u0435\u043d \u0435 \u0441\u043a\u0440\u0438\u043d\u0438\u043d\u0433 \u043d\u0430 \u043d\u044f\u043a\u043e\u0438 \u043e\u0442 \u0442\u0435\u0445\u043d\u0438\u0442\u0435 \u0431\u0438\u043e\u043b\u043e\u0433\u0438\u0447\u043d\u0438 \u0438 \u0444\u0430\u0440\u043c\u0430\u043a\u043e\u043b\u043e\u0433\u0438\u0447\u043d\u0438 \u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0438.<\/span><\/p>\n

\u2981 \u0427\u0440\u0435\u0437 \u043f\u0440\u0438\u043b\u0430\u0433\u0430\u043d\u0435 \u043f\u043e\u0434\u0445\u043e\u0434\u0438\u0442\u0435 \u043d\u0430 \u043c\u043e\u043b\u0435\u043a\u0443\u043b\u043d\u043e\u0442\u043e \u043c\u043e\u0434\u0435\u043b\u0438\u0440\u0430\u043d\u0435 \u0437\u0430 \u043e\u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u0438\u0437\u0438\u0440\u0430\u043d\u0435 \u043d\u0430 \u0432\u0440\u044a\u0437\u043a\u0430\u0442\u0430 \u043c\u0435\u0436\u0434\u0443 \u0441\u0442\u0440\u0443\u043a\u0442\u0443\u0440\u0430\u0442\u0430 \u043d\u0430 \u043d\u043e\u0432\u043e\u0441\u0438\u043d\u0442\u0435\u0437\u0438\u0440\u0430\u043d\u0438\u0442\u0435 \u0445\u0438\u043c\u0438\u0447\u043d\u0438 \u0441\u044a\u0435\u0434\u0438\u043d\u0435\u043d\u0438\u044f \u0438 \u043f\u0440\u043e\u044f\u0432\u0435\u043d\u0438\u044f \u043e\u0442 \u0442\u044f\u0445 \u0431\u0438\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u043d \u0435\u0444\u0435\u043a\u0442 (QSAR \u043c\u043e\u0434\u0435\u043b \u0438 \u043c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u0435\u043d \u0434\u043e\u043a\u0438\u043d\u0433) \u0441\u0435 \u0434\u043e\u043a\u0430\u0437\u0432\u0430 \u043f\u0440\u0438\u043d\u043e\u0441\u0430 \u043d\u0430 \u043e\u0442\u0434\u0435\u043b\u043d\u0438\u0442\u0435 \u0441\u0442\u0440\u0443\u043a\u0442\u0443\u0440\u043d\u0438 \u0444\u0440\u0430\u0433\u043c\u0435\u043d\u0442\u0438 \u0432 \u043f\u043e\u043b\u0443\u0447\u0435\u043d\u0438\u0442\u0435 \u0441\u044a\u0435\u0434\u0438\u043d\u0435\u043d\u0438\u044f \u043a\u044a\u043c \u0430\u043d\u0442\u0438\u043c\u0438\u043a\u043e\u0431\u0430\u043a\u0442\u0435\u0440\u0438\u0430\u043b\u043d\u0430\u0442\u0430 \u0438\u043c \u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442.\u00a0<\/span><\/p>\n

\u2981 \u0421\u044a\u0435\u0434\u0438\u043d\u0435\u043d\u0438\u044f \u0441 R-2-\u0430\u043c\u0438\u043d\u043e-1-\u0431\u0443\u0442\u0430\u043d\u043e\u043b\u043e\u0432 \u043c\u043e\u0442\u0438\u0432, \u043a\u0430\u043c\u0444\u0430\u043d-\u0441\u0432\u044a\u0440\u0437\u0430\u043d\u0438\u0442\u0435 \u0430\u043c\u0438\u043d\u043e\u0430\u043b\u043a\u043e\u0445\u043e\u043b\u0438 \u0438 \u0430\u043c\u0438\u0434\u043e\u0434\u0438\u043e\u043b\u0438 \u043a\u0430\u043a\u0442\u043e \u0438 \u043a\u0443\u043c\u0430\u0440\u0438\u043d, \u0441\u044a\u0434\u044a\u0440\u0436\u0430\u0449\u0438 \u0445\u0438\u0434\u0440\u0430\u0437\u0438\u0434-\u0445\u0438\u0434\u0440\u0430\u0437\u043e\u043d\u043e\u0432\u0438 \u0430\u043d\u0430\u043b\u043e\u0437\u0438 \u0441\u0430 \u0434\u043e\u0441\u0442\u0430 \u043e\u0431\u0435\u0449\u0430\u0432\u0430\u0449\u0438 \u043a\u043b\u0430\u0441\u043e\u0432\u0435 \u0441\u044a\u0435\u0434\u0438\u043d\u0435\u043d\u0438\u044f \u0437\u0430 \u043f\u043e-\u043d\u0430\u0442\u0430\u0442\u044a\u0448\u043d\u043e \u0440\u0430\u0437\u0440\u0430\u0431\u043e\u0442\u0432\u0430\u043d\u0435 \u043d\u0430 \u043d\u043e\u0432\u0438 \u0430\u043d\u0442\u0438\u0442\u0443\u0431\u0435\u0440\u043a\u0443\u043b\u043e\u0437\u043d\u0438 \u0430\u0433\u0435\u043d\u0442\u0438.\u00a0<\/span><\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\u0420\u044a\u043a\u043e\u0432\u043e\u0434\u0438\u0442\u0435\u043b:\u00a0 \u0414\u043e\u0446. \u0434-\u0440 \u041d\u0430\u0434\u044f \u041c\u0430\u0440\u043a\u043e\u0432\u0430, \u0434\u0431 \u0422\u0435\u043b.: +359 2 979 31 61 E-mail: nadya.markova@gmail.com Author ID Scopus (ScienceDirect): 7006844985 https:\/\/www.scopus.com\/authid\/detail.uri?authorId=7006844985 https:\/\/www.researchgate.net\/profile\/Nadya_Markova https:\/\/scholar.google.com\/citations?user=D5NneqEAAAAJ&hl=bg&oi=ao   \u0421\u042a\u0421\u0422\u0410\u0412: \u0414\u043e\u0446. \u0434-\u0440 \u0412\u0438\u043e\u043b\u0435\u0442\u0430 \u0412\u044a\u043b\u0447\u0435\u0432\u0430 \u0422\u0435\u043b.: +359 2 979 31 61 E-mail: violeta_valcheva@mail.bg Author ID Scopus (ScienceDirect): 14061470900, Valcheva, Violeta https:\/\/www.scopus.com\/authid\/detail.uri?authorId=14061470900 https:\/\/www.researchgate.net\/profile\/Violeta_Valcheva\/publications https:\/\/scholar.google.bg\/scholar?hl=en&q=violeta+valcheva&btnG=&as_sdt=1%2C5&as_sdtp=   \u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438 \u043b\u0430\u0431\u043e\u0440\u0430\u043d\u0442 \u0410\u043b\u0431\u0435\u043d\u0430 \u0427\u0435\u0440\u043d\u0435\u0432\u0430 \u0422\u0435\u043b.: +359 2 979 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":794,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/microbio.bas.bg\/wordpress\/index.php\/wp-json\/wp\/v2\/pages\/1179"}],"collection":[{"href":"https:\/\/microbio.bas.bg\/wordpress\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/microbio.bas.bg\/wordpress\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/microbio.bas.bg\/wordpress\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/microbio.bas.bg\/wordpress\/index.php\/wp-json\/wp\/v2\/comments?post=1179"}],"version-history":[{"count":4,"href":"https:\/\/microbio.bas.bg\/wordpress\/index.php\/wp-json\/wp\/v2\/pages\/1179\/revisions"}],"predecessor-version":[{"id":5041,"href":"https:\/\/microbio.bas.bg\/wordpress\/index.php\/wp-json\/wp\/v2\/pages\/1179\/revisions\/5041"}],"up":[{"embeddable":true,"href":"https:\/\/microbio.bas.bg\/wordpress\/index.php\/wp-json\/wp\/v2\/pages\/794"}],"wp:attachment":[{"href":"https:\/\/microbio.bas.bg\/wordpress\/index.php\/wp-json\/wp\/v2\/media?parent=1179"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}