\nACHIEVEMENTS:<\/strong><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n- The foundations of the Laboratory \u201cCytotoxicity and Signal Transduction\u201d, funded by a grant for Assoc. Prof. Maya M. Zaharieva donated by the Alexander von Humboldt Foundation under the Program \u201cEquipment Subsidy\u201d, have been laid. The laboratory was officially opened on April 22, 2015 by Mr. J\u00f6rg Schenk, Head of the Science Department at the Embassy of the Federal Republic of Germany in Sofia. The duration of the Laboratory development was 5 years, as set out in the grant program. During that period a number of projects related to the above mentioned directions were started and successfully finished. The laboratory takes part in several on-going projects: two national scientific programs, five grants funded from the National Bulgarian Scientific Fund, grants in the frame of collaborations with other scientific institutions. A number of graduate and PhD students conducted their practices and training here.<\/span><\/li>\n
- The antibacterial effect and biofilm-inhibitory activity of the new allylphosphocholine erufosine on methicillin-sensitive and resistant strains of the bacterial pathogen Staphylococcus aureus, which is involved in the carcinogenesis of cutaneous T-cell lymphoma (CTCL), were studied for the first time. Combinations between erufosine and curcumin loaded in nano-delivery system with sustained release were investigated for synergistic interactions on cell lines derived from CTCL. It has been proven for the first time that erufosine and the synergistic combinations with curcumin inhibit the expression of the transcription factor TWIST1, which is a prognostic marker for metastasis in patients with CTCL.<\/span><\/li>\n
- The antineoplastic activity and mechanism of action of combinations between Glucuronide Oleanane-type Triterpenoid Carboxylic Acid 3,28-Bidesmosides derived from Gypsophila trichotoma<\/em> Wender roots and the cytostatics etoposide, as well as plant extracts and biologically active compounds isolated from Geum urbanum<\/em> were invstigated for the first time on malignant cell lines of lymphoma and epithelial origin. The toxicological effects of ethyl acetate extract from aerial parts of Geum urbanum<\/em> L. were evaluated in vitro<\/em> on a panel of normal transformed cell lines and in vivo<\/em> on liver, intestinal epithelium and kidney in H albino mice.<\/span><\/li>\n
- The antibacterial effects of Geigeria alata<\/em> (DC) Oliv. & Hiern., Solanum schimperianum<\/em> Hochst and Graptopetalum paraguayense E. <\/em>Walther plant extracts was studied on Gram-positive and Gram-negative pathogenic bacterial species. The antibacterial activity of the plant Geum urbanum<\/em> L was studied partially.<\/span><\/li>\n
- The cytotoxic effect of a number of medical products was evaluated and described under contracts with companies, which is of direct importance for their production and release on the pharmaceutical market.<\/span><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"
Head: Assoc. Prof. Maya M. Zaharieva,\u00a0 PhD Tel.: +359 2 979 31 35 E-mail:\u00a0zaharieva26@gmail.com;\u00a0 m_zaharieva@microbio.bas.bg Author ID Scopus (ScienceDirect): 16302274400, Zaharieva, Maya M. Web of Science ID: ABH-8344-2020 ORCID ID: https:\/\/orcid.org\/0000-0001-8548-5649 https:\/\/www.scopus.com\/authid\/detail.uri?authorId=16302274400 https:\/\/scholar.google.de\/citations?hl=de&user=iCvyndQAAAAJ STAFF: Assist. Prof. Yana Ilieva, PhD Tel.: +359 2 979 31 35 E-mail:\u00a0illievayana@gmail.com Author ID Scopus (ScienceDirect): 57201588764 https:\/\/www2.scopus.com\/authid\/detail.uri?authorId=57201588764 https:\/\/www.researchgate.net\/profile\/Yana_Ilieva Biologist, microbiologist, […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":797,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/microbio.bas.bg\/wordpress\/index.php\/wp-json\/wp\/v2\/pages\/1187"}],"collection":[{"href":"https:\/\/microbio.bas.bg\/wordpress\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/microbio.bas.bg\/wordpress\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/microbio.bas.bg\/wordpress\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/microbio.bas.bg\/wordpress\/index.php\/wp-json\/wp\/v2\/comments?post=1187"}],"version-history":[{"count":10,"href":"https:\/\/microbio.bas.bg\/wordpress\/index.php\/wp-json\/wp\/v2\/pages\/1187\/revisions"}],"predecessor-version":[{"id":6055,"href":"https:\/\/microbio.bas.bg\/wordpress\/index.php\/wp-json\/wp\/v2\/pages\/1187\/revisions\/6055"}],"up":[{"embeddable":true,"href":"https:\/\/microbio.bas.bg\/wordpress\/index.php\/wp-json\/wp\/v2\/pages\/797"}],"wp:attachment":[{"href":"https:\/\/microbio.bas.bg\/wordpress\/index.php\/wp-json\/wp\/v2\/media?parent=1187"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}} |
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