{"id":700,"date":"2017-11-02T14:13:53","date_gmt":"2017-11-02T11:13:53","guid":{"rendered":"http:\/\/microbio.bas.bg\/wordpress\/?page_id=700"},"modified":"2021-01-03T23:45:15","modified_gmt":"2021-01-03T20:45:15","slug":"laboratory-of-microbial-biochemistry","status":"publish","type":"page","link":"https:\/\/microbio.bas.bg\/wordpress\/index.php\/en\/structure\/scientific-staff\/department-of-general-microbiology\/laboratory-of-microbial-biochemistry\/","title":{"rendered":"LABORATORY OF MICROBIAL BIOCHEMISTRY"},"content":{"rendered":"<p><span style=\"font-size: 14pt; font-family: arial, helvetica, sans-serif;\">Head: Assist. Prof. Rumyana Eneva<\/span><\/p>\n<p class=\"clear-margins\"><span style=\"font-family: arial, helvetica, sans-serif;\">Tel.: +359 2 979 31 47<\/span><\/p>\n<p class=\"clear-margins\"><span style=\"font-family: arial, helvetica, sans-serif;\">E-mail:\u00a0<a href=\"mailto:rum_eneva@abv.bg\" target=\"_blank\" rel=\"noopener\">rum_eneva@abv.bg<\/a><\/span><\/p>\n<p><span style=\"color: #0000ff;\"><u><a href=\"https:\/\/orcid.org\/0000-0001-6905-6190\"><span style=\"font-family: Arial, serif;\"><span style=\"font-size: small;\">https:\/\/orcid.org\/0000-0001-6905-6190<\/span><\/span><\/a><\/u><\/span><\/p>\n<p><span style=\"color: #0000ff;\"><u><a href=\"https:\/\/www.scopus.com\/authid\/detail.uri?authorId=36443540100\">https:\/\/www.scopus.com\/authid\/detail.uri?authorId=36443540100<\/a><\/u><\/span><\/p>\n<table style=\"background-color: #f0f1f5; width: 100%; height: 60px;\">\n<tbody>\n<tr>\n<td style=\"text-align: center;\"><span style=\"font-size: 18pt;\"><strong><span style=\"font-family: arial, helvetica, sans-serif;\">STAFF:<\/span><\/strong><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">Assoc. Prof. Blaga Mutafova, PhD<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">Tel.: +359 2 979 31 54<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">\u0415-mail: <a href=\"mailto:blaga@microbio.bas.bg\">blaga@microbio.bas.bg<\/a><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">Assist. Prof. Nelly Christova, PhD<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">Tel.: +359 2 979 31 15<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">\u0415-mail: <a href=\"mailto:nchrist@abv.bg\">nchrist@abv.bg<\/a><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">Assist. Prof. Rumyana Eneva, PhD<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">Tel.: +359 2 979 31 47<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">\u0415-mail: <a href=\"mailto:rum_eneva@abv.bg\">rum_eneva@abv.bg<\/a><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">Assist. Prof. Yana Gocheva, PhD<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">Tel.: +359 2 979 63 56<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">E-mail:\u00a0<a href=\"mailto:yanagocheva@microbio.bas.bg\">yanagocheva@microbio.bas.bg<\/a><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">Assist. Anna Sotirova, MS<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">Tel.: +359 2 979 31 39<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">\u0415-mail: <a href=\"mailto:anna@microbio.bas.bg\">anna@microbio.bas.bg<\/a><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">Assist. Stephan Engibarov, MS<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">Tel.: +359 2 979 31 47<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">\u0415-mail: <a href=\"mailto:stefan_engibarov@abv.bg\">stefan_engibarov@abv.bg<\/a><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">Assist. Irina Lazarkevich, MS<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">Tel.: +359 2 979 31 39<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">\u0415-mail: <a href=\"mailto:irinalazarkevich@abv.bg\">irinalazarkevich@abv.bg<\/a><strong>\u00a0<\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<table style=\"background-color: #f0f1f5; height: 60px;\" width=\"100%\">\n<tbody>\n<tr>\n<td style=\"text-align: center;\"><span style=\"font-size: 18pt; font-family: arial, helvetica, sans-serif;\"><strong>CURRENT RESEARCH TOPICS: \u00a0<\/strong><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul>\n<li><span style=\"font-family: arial, helvetica, sans-serif;\">Microbial enzymes: isolation, purification, properties, biological role.<\/span><\/li>\n<li><span style=\"font-family: arial, helvetica, sans-serif;\">Characterization and study of microbial sialidases produced by bacteria and filamentous fungi. Study of new producers of sialidase among pathogenic and saprophytic microorganisms.<\/span><\/li>\n<li><span style=\"font-family: arial, helvetica, sans-serif;\">Microbial transformation of steroid compounds and biologically active compounds of plant origin.<\/span><\/li>\n<li><span style=\"font-family: arial, helvetica, sans-serif;\">Biologically active substances of microbial and synthetic origin- antimicrobial activity, mechanisms of action.<\/span><\/li>\n<li><span style=\"font-family: arial, helvetica, sans-serif;\">Microbial surfactants (biosurfactants) \u2013 biosynthesis, isolation, purification, physical chemical properties; effect on microbial cell surface properties; application in\u00a0medical, pharmacological and environmental biotechnologies.<\/span><\/li>\n<li class=\"staff\" style=\"text-align: justify;\"><span style=\"font-family: arial, helvetica, sans-serif;\">Characterization and biosynthetic potential of new microbial strains isolated from extreme ecological niches for production of enzymes, antimicrobials, etc.<\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<table style=\"background-color: #f0f1f5; width: 100%; height: 60px;\">\n<tbody>\n<tr>\n<td style=\"text-align: center;\"><span style=\"font-family: arial, helvetica, sans-serif;\"><span style=\"font-size: 18pt;\"><strong>PROJECTS:<\/strong><\/span>.<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul>\n<li><span class=\"tlid-translation translation\" lang=\"en\" style=\"font-family: arial, helvetica, sans-serif;\">DN-01\/13 of 2016 &#8222;Role of amaryllis alkaloids in the endophyte-host relationship&#8220;. Duration 3 years. Leading organization: Institute of Biodiversity and Ecosystem Research &#8211; BAS. Leader: Prof. Strahil Berkov. Funding: NSF at the Ministry of Education and Science.<\/span><\/li>\n<li><span class=\"tlid-translation translation\" lang=\"en\" style=\"font-family: arial, helvetica, sans-serif;\">DN-16\/2 of 2017 &#8222;Biocidal activity of extracts of Bulgarian plants-screening and protection of potato plantations&#8220;. Duration 3 years. Leading organization: Institute of Biodiversity and Ecosystem Research &#8211; BAS. Supervisor: Assoc. Prof. Dr. Milena Nikolova. Funding: NSF at the Ministry of Education and Science.<\/span><\/li>\n<li><span class=\"tlid-translation translation\" lang=\"en\" style=\"font-family: arial, helvetica, sans-serif;\">KP-06-21 \/ 13 of 2018 &#8222;New enzymes from the group of sialidases in filamentous fungi&#8220;. Duration 3 years. Leading organization: Stefan Angelov Institute of Microbiology &#8211; BAS. Supervisor: Assoc. Prof. Dr. Radoslav Abrashev. Funding: NSF at the Ministry of Education and Science.<\/span><\/li>\n<li><span class=\"tlid-translation translation\" lang=\"en\" style=\"font-family: arial, helvetica, sans-serif;\">KP-06-N37 \/ 27 of 18.12.2019 &#8222;Intelligent textile materials with environmental and biomedical applications&#8220;. Duration 3 years. Leading organization: University of Chemical Technology and Metallurgy &#8211; Sofia. Supervisor: Assoc. Prof. Dr. Eng. Desislava Staneva. Funding: NSF at the Ministry of Education and Science.<\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<table style=\"background-color: #f0f1f5; width: 100%; height: 60px;\">\n<tbody>\n<tr>\n<td style=\"text-align: center;\"><span style=\"font-size: 18pt; font-family: arial, helvetica, sans-serif;\"><strong>SELECTED PUBLICATIONS:<\/strong><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ol>\n<li><span style=\"font-family: arial, helvetica, sans-serif;\">Vasileva-Tonkova, E., Staneva, D., Medel, S., Bosch, P., Grozdanov, P., Nikolova, I., Grabchev, I. Antimicrobial, antibiofilm and cytotoxicity activity of a new acridine hyperbranched polymer in solution and on cotton fabric. <em>Fibers and Polymers<\/em>, 20, 2019, 19-24.<\/span><\/li>\n<li><span style=\"font-family: arial, helvetica, sans-serif;\">Staneva, D., Vasileva-Tonkova, E., Grabchev, I. Chemical modification of cotton fabric with 1,8-naphthalimide for use as heterogeneous sensor and antibacterial textile. <em>Journal of Photochemistry and Photobiology A: Chemistry<\/em>, 382, 2019, 111924.<\/span><\/li>\n<li><span style=\"font-family: arial, helvetica, sans-serif;\">Staneva, D., <strong>Vasileva-Tonkova, E.<\/strong><strong>,<\/strong> Grabchev, I. A New Bioactive Complex between Zn(II) and a Fluorescent Symmetrical Benzanthrone Tripod for an Antibacterial Textile. <em>Materials<\/em>, 12, 2019, 3473.<\/span><\/li>\n<li><span style=\"font-family: arial, helvetica, sans-serif;\">R. Abrashev, E. Krumova, R. Eneva, N. Kostadinova, J. Miteva-Staleva, S. Engibarov, G. Stoyancheva, Y. Gocheva, V. Kolyovsk\u0430, P. Petrova, V. Dishliyska, B. Spassova, M. Angelova. Distribution of sialidase in filamentous fungal strains from different sources. 11<sup>th<\/sup> Balkan Congress of Microbiology \u2013 Microbiologia Balkanica 2019 (21-23.11.2019). \u0414\u043e\u043a\u043b\u0430\u0434.<\/span><\/li>\n<li><span style=\"font-family: arial, helvetica, sans-serif;\">Mutafova, B., Momchilova, S., Pomakova, D., Avramova, T., Mutafov, S. Enhanced cell surface hydrophobicity favors the 9\u03b1-hydroxylation of androstenedione by resting <em>Rhodococcus <\/em>sp. cells. <em>Engineering in<\/em> <em>Life<\/em> <em>Sciences<\/em>, 18, 2018, 949-954. DOI: 10.1002\/elsc.201800089<\/span><\/li>\n<li><span style=\"font-family: arial, helvetica, sans-serif;\">Boyadzhieva, I., Radchenkova, N, Tomova, I., Kambourova, M., Poli, A., Vasileva-Tonkova, E. Diversity of Heterotrophic Halophilic Bacteria Isolated from Coastal Solar Salterns, Bulgaria and Their Ability to Synthesize Bioactive Molecules with Biotechnological Impact. <em>Microbiology<\/em>, 87, 2018, 519-528.<\/span><\/li>\n<li><span style=\"font-family: arial, helvetica, sans-serif;\">Vasileva-Tonkova, E., Grozdanov, P., Nikolova, I., Staneva, D., Bosch, P., Medel, S., Grabchev, I. Evaluation of antimicrobial, biofilm inhibitory and cytotoxic activities of a new hiperbranched polymer modified with 1, 8-naphthalimide units. <em>BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY<\/em>, 8, 2018, 3053-3059.<\/span><\/li>\n<li><span style=\"font-family: arial, helvetica, sans-serif;\">Mutafova, B., Mutafov, S., Fernandes, P., Berkov, S. Microbial transformations of plant origin compounds as a step in preparation of highly valuable pharmaceuticals. <em>Journal of Drug Metabolism and Toxicology<\/em>, 7, 2016, 204, DOI:10.4172\/2157-7609.1000204<\/span><\/li>\n<li><span style=\"font-family: arial, helvetica, sans-serif;\">Mutafova B., Fernandes P., Mutafov S., Berkov S., Pavlov A. (2016) Microbial Transformations of Plant Secondary Metabolites. Chapter in: Pavlov A., Bley T. (eds) Bioprocessing of Plant In Vitro Systems. <em>Reference Series in Phytochemistry<\/em>. Springer, Cham; DOI: 10.1007\/978-3-319-54600-1_15<\/span><\/li>\n<li><span style=\"font-family: arial, helvetica, sans-serif;\">Hristov, A., Christova, N., Kabaivanova, L, Nacheva, L., Stoineva, I., Petrov, P. Simultaneous Biodegradation of Phenol and n-Hexadecane by Cryogel Immobilized Biosurfactant Producing Strain <em>Rhodococcus wratislawiensis<\/em> BN38. <em>Polish Journal of Microbiology<\/em>, 65, 2016, 287-293.<\/span><\/li>\n<li><span style=\"font-family: arial, helvetica, sans-serif;\">Christova, N., Lang, S., Wray, V., Kaloyanov, K., Konstantinov, S., Stoineva, I. Production, structural elucidation and <em>in vitro<\/em> antitumor activity of trehalose lipid biosurfactant from <em>Nocardia farcinica<\/em> strain. <em>Journal of Microbiology and Biotechnology<\/em>, 25, 2015, 439-447.<\/span><\/li>\n<li><span style=\"font-family: arial, helvetica, sans-serif;\">Eneva, R., Engibarov, S., Petrova, P., Abrashev, R., Strateva, T., Kolyovska, V., Abrashev, I. High production of neuraminidase by a <em>Vibrio cholerae<\/em> Non -O1 strain \u2013 the first possible alternative to toxigenic producers. <em>Applied Biochemistry and Biotechnology<\/em>, 176, 2015, 412-427.<\/span><\/li>\n<li><span style=\"font-family: arial, helvetica, sans-serif;\">Engibarov, S., Eneva, R., Abrashev, I. Neuraminidase (sialidase) from <em>Aeromonas<\/em> sp. strain A\/40 \u2013 isolation and partial purirfication. <em>Annals of Microbiology<\/em>, 65, 2015, 1515-1523.<\/span><\/li>\n<li><span style=\"font-family: arial, helvetica, sans-serif;\">Lazarkevich, I., Sotirova, A., Avramova, T., Galabova, D. Comparative study on antibacterial activity of synthetic analogues of biologically active compounds and their combination with rhamnolipid-biosurfactant. <em>Journal of BioScience and Biotechnol<\/em>ogy, 2015, SE\/ONLINE: 55-62.<\/span><\/li>\n<li><span style=\"font-family: arial, helvetica, sans-serif;\">Tomova, I., Stoilova-Disheva, M., Lazarkevich, I., Vasileva-Tonkova, E. Antimicrobial activity and resistance to heavy metals and antibiotics of heterotrophic bacteria isolated from sediment and soil samples collected from two Antarctic islands. <em>Frontiers in Life Science<\/em>, 8, 2015, 348-357.<\/span><\/li>\n<li><span style=\"font-family: arial, helvetica, sans-serif;\">Berkov, S., Mutafova, B., Christen, P. Molecular biodiversity and recent analytical developments: A marriage of convenience. <em>Biotechnology Advances<\/em>, 32, 2014, 1102-1110.<\/span><\/li>\n<li><span style=\"font-family: arial, helvetica, sans-serif;\">Terziyski, I., Stoineva, I., Christova, N., Alexandrova, L., Todorov, R., Cohen, R. Foam and wetting films from rhamnolipids produced by <em>Pseudomonas aeruginosa<\/em> BN10<em>. Colloids and Surfaces<\/em><em> A<\/em><em>: Physicochemical and Engineering Aspects<\/em>, 460, 2014, 299-305.<\/span><\/li>\n<li><span style=\"font-family: arial, helvetica, sans-serif;\">Galabova, D., Sotirova, A., Karpenko, E., Karpenko, O. Role of microbial surface-active compounds in environmental protection. In: M. Fanun (ed.), The role of colloidal systems in environmental protection. Chapter 3, 2014, Amsterdam: Elsevier, pp. 41-83.\u00a0 ISBN: 978-0-444-63283-8<\/span><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<table style=\"background-color: #f0f1f5; height: 60px;\" width=\"100%\">\n<tbody>\n<tr>\n<td style=\"text-align: center;\"><span style=\"font-size: 18pt; font-family: arial, helvetica, sans-serif;\"><strong>ACHIEVEMENTS: \u00a0<\/strong><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\">Article with more than 165 citations:<\/span><\/p>\n<ul>\n<li><span style=\"font-family: arial, helvetica, sans-serif;\">Fernandes, P., Cruz, A., Angelova, B., Pinheiro, H.M., Cabral, J.M.S. Microbial conversion of steroid compounds: recent developments. Enzyme and Microbial Technology, 32(6), 2003, 688-705.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-family: arial, helvetica, sans-serif;\"><a href=\"https:\/\/www.scopus.com\/record\/display.uri?eid=2-s2.0-0037457699&amp;origin=resultslist&amp;sort=plf-f&amp;src=s&amp;st1=Angelova&amp;st2=B&amp;nlo=1&amp;nlr=20&amp;nls=count-f&amp;sid=4545E4E93E356C25D32CD305192EEAE2.wsnAw8kcdt7IPYLO0V48gA%3a313&amp;sot=anl&amp;sdt=aut&amp;sl=35&amp;s=AU-ID%28%22Angelova%2c+Blaga%22+8787227400%29&amp;relpos=0&amp;citeCnt=291&amp;searchTerm\">https:\/\/www.scopus.com\/record\/display.uri?eid=2-s2.0-0037457699&amp;origin=resultslist&amp;sort=plf-f&amp;src=s&amp;st1=Angelova&amp;st2=B&amp;nlo=1&amp;nlr=20&amp;nls=count-f&amp;sid=4545E4E93E356C25D32CD305192EEAE2.wsnAw8kcdt7IPYLO0V48gA%3a313&amp;sot=anl&amp;sdt=aut&amp;sl=35&amp;s=AU-ID%28%22Angelova%2c+Blaga%22+8787227400%29&amp;relpos=0&amp;citeCnt=291&amp;searchTerm<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Head: Assist. Prof. Rumyana Eneva Tel.: +359 2 979 31 47 E-mail:\u00a0rum_eneva@abv.bg https:\/\/orcid.org\/0000-0001-6905-6190 https:\/\/www.scopus.com\/authid\/detail.uri?authorId=36443540100 STAFF: Assoc. Prof. Blaga Mutafova, PhD Tel.: +359 2 979 31 54 \u0415-mail: blaga@microbio.bas.bg &nbsp; Assist. Prof. Nelly Christova, PhD Tel.: +359 2 979 31 15 \u0415-mail: nchrist@abv.bg &nbsp; Assist. Prof. Rumyana Eneva, PhD Tel.: +359 2 979 31 47 \u0415-mail: [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":609,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/microbio.bas.bg\/wordpress\/index.php\/wp-json\/wp\/v2\/pages\/700"}],"collection":[{"href":"https:\/\/microbio.bas.bg\/wordpress\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/microbio.bas.bg\/wordpress\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/microbio.bas.bg\/wordpress\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/microbio.bas.bg\/wordpress\/index.php\/wp-json\/wp\/v2\/comments?post=700"}],"version-history":[{"count":8,"href":"https:\/\/microbio.bas.bg\/wordpress\/index.php\/wp-json\/wp\/v2\/pages\/700\/revisions"}],"predecessor-version":[{"id":5145,"href":"https:\/\/microbio.bas.bg\/wordpress\/index.php\/wp-json\/wp\/v2\/pages\/700\/revisions\/5145"}],"up":[{"embeddable":true,"href":"https:\/\/microbio.bas.bg\/wordpress\/index.php\/wp-json\/wp\/v2\/pages\/609"}],"wp:attachment":[{"href":"https:\/\/microbio.bas.bg\/wordpress\/index.php\/wp-json\/wp\/v2\/media?parent=700"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}