The Stephan Angeloff Institute of Microbiology
Member Of The International Institut Pasteur Network
Head: Assoc. Prof. Violeta Valcheva, PhD
Tel.: +359 2 979 31 61
E-mail: violeta_valcheva@mail.bg
Author ID Scopus (ScienceDirect): 14061470900, Valcheva, Violeta
ttps://www.scopus.com/authid/detail.uri?authorId=14061470900
https://www.researchgate.net/profile/Violeta_Valcheva/publications
https://scholar.google.bg/scholar?hl=en&q=violeta+valcheva&btnG=&as_sdt=1%2C5&as_sdtp=
STAFF: |
Tel.: +359 2 979 31 61
E-mail: violeta_valcheva@mail.bg
Author ID Scopus (ScienceDirect): 14061470900, Valcheva, Violeta
https://www.scopus.com/authid/detail.uri?authorId=14061470900
https://www.researchgate.net/profile/Violeta_Valcheva/publications
https://scholar.google.bg/scholar?hl=en&q=violeta+valcheva&btnG=&as_sdt=1%2C5&as_sdtp=
MAIN TOPICS OF RESEARCH: |
⦁ Molecular epidemiology, phylogenetics and evolution of mycobacteria (DNA isolates from Mycobacterium tuberculosis complex : Mycobacterium tuberculosis and Mycobacterium bovis). ⦁ Application of bioinformatics tools for analysis of mycobacteria. ⦁ Screening of newly synthesized compounds for their in vitro antimycobacterial activity. ⦁ Mycobacteria and L-transformation, latent tuberculosis, BCG vaccine, placental microbiome and immunological phenomenon during pregnancy & blood microbiota ⦁ Development of molecular-biological tools for detection and identification of mycobacterial L-forms. ⦁ Molecular mechanisms of drug resistance and tolerance in mycobacteria.
SELECTED PUBLICATIONS: |
Head: Assoc. Prof. Violeta Valcheva, PhD
Tel.: +359 2 979 31 61
E-mail: violeta_valcheva@mail.bg
STAFF: |
Assoc. Prof. d-r Violeta Valcheva
Tel.: +359 2 979 31 61
E-mail: violeta_valcheva@mail.bg
Author ID Scopus (ScienceDirect): 14061470900, Valcheva, Violeta
ttps://www.scopus.com/authid/detail.uri?authorId=14061470900
https://www.researchgate.net/profile/Violeta_Valcheva/publications
https://scholar.google.bg/scholar?hl=en&q=violeta+valcheva&btnG=&as_sdt=1%2C5&as_sdtp=
Technician Albena Cherneva Tel.: +359 2 979 31 61 E-mail: albenacherneva@abv.bg
MAIN TOPICS OF RESEARCH: |
⦁ Molecular epidemiology, phylogenetics and evolution of mycobacteria (DNA isolates from Mycobacterium tuberculosis complex : Mycobacterium tuberculosis and Mycobacterium bovis). ⦁ Application of bioinformatics tools for analysis of mycobacteria. ⦁ Screening of newly synthesized compounds for their in vitro antimycobacterial activity. ⦁ Mycobacteria and L-transformation, latent tuberculosis, BCG vaccine, placental microbiome and immunological phenomenon during pregnancy & blood microbiota ⦁ Development of molecular-biological tools for detection and identification of mycobacterial L-forms. ⦁ Molecular mechanisms of drug resistance and tolerance in mycobacteria.
SELECTED PUBLICATIONS: |
Valcheva, V., Perea, C., Savova-Lalkovska, T., Dimitrova, A., Radulski, L., Mokrousov, I., Bonovska, M. Mycobacterium bovis and M. caprae in Bulgaria: insight into transmission and phylogeography gained through whole-genome sequencing. BMC veterinary research, 2022. 18 (1), 1-12. doi https://doi.org/10.1186/s12917-022-03249-w
Slavchev, I. M., Mitrev, Y., Shivachev, B., Valcheva, V., Dogonadze, M., Solovieva, N., Dobrikov, G. M. Synthesis, Characterization and Complex Evaluation of Antibacterial Activity and Cytotoxicity of New Arylmethylidene Ketones and Pyrimidines with Camphane Skeletons. ChemistrySelect, 202 7(17), e202201339. https://doi.org/10.1002/slct.202201339
Angelova, V. T., Pencheva, T., Vassilev, N., K-Yovkova, E., Mihaylova, R., Petrov, B., Valcheva, V. Development of New Antimycobacterial Sulfonyl Hydrazones and 4-Methyl-1, 2, 3-thiadiazole-Based Hydrazone Derivatives. Antibiotics, 2022. 11(5), 562. https://doi.org/10.3390/antibiotics11050562
Chimshirova, R., Popova, M., Chakir, A., Valcheva, V., Dimitrov, S., Trusheva, B., Bankova, V. Antimicrobial triterpenoids and ingol diterpenes from propolis of semi-arid region of Morocco. Molecules, 2022. 27(7), 2206. https://doi.org/10.3390/molecules27072206
Mileva, M, Ilieva, Y, Jovtchev, G, Gateva, S, Zaharieva, MM, Georgieva, A, Dimitrova, L, Dobreva, A, Angelova, Ts, Vilhelmova-Ilieva, N, Valcheva, V, Najdenski, H. Rose flowers—A Delicate Perfume or a Natural Healer?. Biomolecules, 2021, 11, 1, doi:https://doi.org/10.3390/biom11010127, 127-159.
Valcheva V., SavovaLalkovska T., Vyazovaya A., Dimitrova A. Bonovska M. Najdenski H First insight into phylogeography of Mycobacterium bovis and Mycobacterium caprae from cattle in Bulgaria. Infection, Genetics and Evolution, 2020, doi: 10.1016/j.meegid.2020.104240
Savova-Lalkovska T., Bonovska M., Dimitrova A., Valcheva V., Petkov Y., Hadjieva G., Najdenski H. Evaluation of classical and rapid methods for isolation and identification of Mycobacterium bovis in cattle in Bulgaria. Bulgarian Journal of Veterinary Medicine, 2019, doi: 10.15547/bjvm.2289 .
Georgieva K., Trusheva B., Uzunova V., Stoyanova T., Valcheva V., Popova M., Bankova V. New cycloartane triterpenes from bioactive extract of propolis from Pitcairn Island. Fitoterapia, 2018, 128: 233-241. doi: 10.1016/j.fitote.20105.024.
Doncheva, T., Kostova, N., Valcheva, V., Toshkovska, R., Vutov, V., Philipov, S. Hypepontine, a new quaternary alkaloid with antimicrobial properties. Natural product research, 2018, 1-7. doi:10.1080/14786412018.1495640
Yanev, S., Stoyanova, T., Valcheva V., De Montellano, O. Xanthates: Metabolism by Flavoprotein-Containing Monooxygenases and Antimycobacterial Activity. Drug Metabolism and Disposition, 2018. 46(8), 1091-1095. DOI:1124/dmd.118.081984, 1091-1095
Philipova, I., Valcheva, V., Mihaylova, R., Mateeva, M., Doytchinova, I. and Stavrakov, G., Synthetic piperine amide analogues with antimycobacterial activity. Chem biology & drug design. 2017. doi: 10.1111/cbdd.13140
Mokrousov, I., Chernyaeva, E., Vyazovaya, A., Skiba, Y., Solovieva, N., Valcheva, V., Levina, K., Malakhova, N., Jiao, W.W., Gomes, L.L. and Suffys, P.N., A rapid assay for detection of the epidemiologically important Central Asian/Russian strain of the Mycobacterium tuberculosis Beijing genotype. J Clin Microbiol. 2017. pii: JCM.01551-17. doi: 10.1128/JCM.01551-17
Angelova, V., Valcheva, V., Pencheva, T., Voynikov, Y., Vassilev, N., Mihaylova, R., Momekov, G. and Shivachev, B., Synthesis, antimycobacterial activity and docking study of 2-aroyl-[1] benzopyrano [4, 3-c] pyrazol-4 (1H)-one derivatives and related hydrazide-hydrazones. Bioorg Med Chem Lett, 2017. 27 (13): 2996-3002. doi: 10.1016/j.bmcl.2017.05.011
Angelova V., Valcheva V, Vassilev N.G, Buyukliev R, Momekov G, Dimitrov I, Saso L, Djukic M, Shivachev B. Antimycobacterial activity of novel hydrazide-hydrazone derivatives with 2H-chromene and coumarin scaffold. Bioorg Med Chem Lett. 2017; 27(2): 223-227. doi: 10.1016/j.bmcl.2016.11.071.
Mokrousov I, Vyazovaya A, Iwamoto T, Skiba Y, Pole I, Zhdanova S, Arikawa K, Sinkov V, Umpeleva T, Valcheva V, Alvarez Figueroa M, Ranka R, Jansone I, Ogarkov O, Zhuravlev V, Narvskaya O. Latin-American-Mediterranean lineage of Mycobacterium tuberculosis: Human traces across pathogen's phylogeography. Mol Phylogenet Evol. 2016. 99:133-143. doi: 10.1016/j.ympev.2016.03.020.
Valcheva V., Rastogi, N., Mokrousov, I. Prevalence of Latin-American-Mediterranean genetic family in population structure of Mycobacterium tuberculosis in Bulgaria. Int. J of Mycobacteriology. 2015. 4(1): 22-23; doi:10.1016/j.ijmyco.2014.10.044
Slavchev I, Dobrikov GM, Valcheva V, Ugrinova I, Pasheva E, Dimitrov V. Antimycobacterial activity generated by the amide coupling of (-)-fenchone derived aminoalcohol with cinnamic acids and analogues. Bioorg Med Chem Lett. 2014 ; 24 (21): 5030-3.
Voynikov Y, Valcheva V, Momekov G, Peikov P, Stavrakov G. Theophylline-7-acetic acid derivatives with amino acids as anti-tuberculosis agents. Bioorg Med Chem Lett. 2014. pii: S0960-894X(14)00526-5. doi: 10.1016/j.bmcl.2014.05.026.
Stavrakov G, Valcheva V, Philipova I, Doytchinova I Design of novel camphane-based derivatives with antimycobacterial activity. J Mol Graph Model. 2014. 51C:7-12. Petkova Z, Valcheva V, Momekov G, Petrov P, Dimitrov V, Doytchinova I, Stavrakov G, Stoyanova M. Antimycobacterial activity of chiral aminoalcohols with camphane scaffold. Eur J Med Chem. 2014. 81C:150-157.
Dobrikov GM, Valcheva V, Nikolova Y, Ugrinova I, Pasheva E, Dimitrov V. Enantiopure antituberculosis candidates synthesized from (-)-fenchone. Eur J Med Chem. 2014. 77:243-7.
Stavrakov G, Philipova I, Valcheva V, Momekov G. Synthesis and antimycobacterial activity of novel camphane-based agents. Bioorg Med Chem Lett. 2014. 24(1):165-7.
Stavrakov G, Valcheva V, Philipova I, Doytchinova I. Novel camphane-based anti-tuberculosis agents with nanomolar activity. Eur J Med Chem. 2013. 70:372-9.
Dobrikov GM, Valcheva V, Nikolova Y, Ugrinova I, Pasheva E, Dimitrov V. Efficient synthesis of new (R)-2-amino-1-butanol derived ureas, thioureas and acylthioureas and in vitro evaluation of their antimycobacterial activity. Eur J Med Chem. 2013. 63: 468-73.
Dobrikov GM, Valcheva V, Stoilova-Disheva M, Momekov G, Tzvetkova P, Chimov A, Dimitrov V. Synthesis and in vitro antimycobacterial activity of compounds derived from (R)- and (S)-2-amino-1-butanol - The crucial role of the configuration. Eur J Med Chem. 2012. 48:45-56
Valcheva V., Mokrousov I., Panaiotov S., Bachiiska E., Zozio T., Sola C., Markova N., Rastogi N. Bulgarian specificity and controversial phylogeography of Mycobacterium tuberculosis spoligotype ST125_BGR. FEMS Immunol Med Microbiol. 2010. 59: 90-99.
Valcheva V., Mokrousov I., Narvskaya O., Rastogi N., Markova N. Utility of new 24-locus variable-number tandem-repeat typing for discriminating Mycobacterium tuberculosis clinical isolates collected in Bulgaria. J. Clin. Microbiol. 2008.46: 3005-3011
Valcheva V., Mokrousov I., Narvskaya O., Rastogi N., Markova N. Molecular snapshot of drug-resistant and drug-susceptible Mycobacterium tuberculosis strains circulating in Bulgaria. Infect. Genet. Evol. 2008. 8: 657-663.
Valcheva V., Mokrousov I., Rastogi N., Narvskaya O., Markova N. Molecular characterization of Mycobacterium tuberculosis isolates from different regions of Bulgaria. J Clin Microbiol. 2008. 46:1014-1018.
ACHIEVEMENTS: |
Molecular Genetic Research :
Blood microbiota:
Acad. Georgi Bonchev street
blok. 26, Sofia, zip 1113
tel.: +359 2 979 31 57
+359 879 499 167
e-mail: micb@microbio.bas.bg
Cellular Biosystems Laboratory
Plovdiv, zip 4000
139, Ruski blvd.
Manager: soc. Prof. Dr. Vasil Georgiev
Metabolomica Laboratory
Plovdiv, zip 4000
139, Ruski blvd.
Manager: Prof. Dr. Milen Georgiev
Laboratory “Ecology of pathogenic bacteria”
Veliko Tarnovo, zip 5002
78 Nikola Gabrovski Str., floor. 4
Manager: Ch. Assistant Professor Dr. Zvezdimira Tsvetanova