The Stephan Angeloff Institute of Microbiology
Member Of The International Institut Pasteur Network
E-mail: nina@microbio.bas.bg
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The results of the Laboratory of Infectious Immunology and Inflammation contribute to the experimental immunology and immunotherapy. The elaborated experimental mouse models of rheumatoid arthritis and osteoarthritis allow the investigation of the pathogenesis of joint disorders and are suitable for evaluation of potential anti-arthritic agents. The main topics of the laboratory are: 1) to dissect key biological and molecular pathways in acute and chronic inflammatory disorders and diseases, and to understand their relevance to the disease pathology, and 2) to develop new tools and approaches for the prediction, prevention and management of the abnormal immune responses. For the first time, the relationship between the mechanisms of innate immunity (complement system) and the processes of joint destruction has been established and an in vitro model for generation of erosive cells has been developed. With clinical meaning are the results obtained in arthritic patients, which help the identification of biochemical markers characteristic for active and inactive arthritic process. For the first time, the mechanism of action of tyrosine kinase inhibitor tyrphostin AG490 in a model of osteoarthritis has been studied precisely.
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Acad. Georgi Bonchev street
blok. 26, Sofia, zip 1113
tel.: +359 2 979 31 57
+359 879 499 167
e-mail: micb@microbio.bas.bg
Cellular Biosystems Laboratory
Plovdiv, zip 4000
139, Ruski blvd.
Manager: soc. Prof. Dr. Vasil Georgiev
Metabolomica Laboratory
Plovdiv, zip 4000
139, Ruski blvd.
Manager: Prof. Dr. Milen Georgiev
Laboratory “Ecology of pathogenic bacteria”
Veliko Tarnovo, zip 5002
78 Nikola Gabrovski Str., floor. 4
Manager: Ch. Assistant Professor Dr. Zvezdimira Tsvetanova